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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56348
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dc.creatorPatricia P. Garcezpt_BR
dc.creatorGabriela Vitóriapt_BR
dc.creatorPatricia C. Sequeirapt_BR
dc.creatorJaroslaw Sochackipt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorHellen Thais Fuziipt_BR
dc.creatorAna Maria Bispo de Filippispt_BR
dc.creatorJoão Lídio da Silva Gonçalves Vianez Júniorpt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorDaniel Martins de Souzapt_BR
dc.creatorStevens K. Rehenpt_BR
dc.creatorJuliana Minardi Nascimentopt_BR
dc.creatorJanaina Mota de Vasconcelospt_BR
dc.creatorRodrigo Madeiro da Costapt_BR
dc.creatorRodrigo Delvecchiopt_BR
dc.creatorPablo Trindadept_BR
dc.creatorErick Correia Loiolapt_BR
dc.creatorLuiza M. Higapt_BR
dc.creatorJuliana Silva Cassolipt_BR
dc.date.accessioned2023-07-15T00:13:44Z-
dc.date.available2023-07-15T00:13:44Z-
dc.date.issued2017-
dc.citation.volume7pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doi10.1038/srep40780 (2017)pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56348-
dc.description.resumoZika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectZika viruspt_BR
dc.subjectMicrocephalypt_BR
dc.subjectBrainpt_BR
dc.subject.otherVírus da Zikapt_BR
dc.subject.otherMicrocefaliapt_BR
dc.subject.otherFeto - Cerebro - Anomaliaspt_BR
dc.titleZika virus disrupts molecular fingerprinting of human neurospherespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/srep40780#Sec3pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9107-1335pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4415-3837pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0616-3543pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9815-9022pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9420-6143pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1117-9099pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4216-9501pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3126-4984pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5646-8858pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2951-3964pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5953-7054pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7926-795Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2174-6309pt_BR
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