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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56350
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dc.creatorFernanda L. Castropt_BR
dc.creatorAlessandro L. Gonçalvespt_BR
dc.creatorDaniela P. Cunhapt_BR
dc.creatorMaria Elisabeth Moreirapt_BR
dc.creatorZilton Farias Meira de Vasconcelospt_BR
dc.creatorLeila Chimelipt_BR
dc.creatorAdriana Melopt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorDouglas Nixonpt_BR
dc.creatorMarcelo Ribeiro Alvespt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorVictor Geddespt_BR
dc.creatorFábio Luís Lima Monteiropt_BR
dc.creatorRaphael M. D. T. Gonçalvespt_BR
dc.creatorLoraine Campanati Araujo de Andradept_BR
dc.creatorPaula Pezzutopt_BR
dc.creatorDominic Paquin Proulxpt_BR
dc.creatorBruno Luiz Fonseca Schamber Reispt_BR
dc.creatorGirlene S. Azevedopt_BR
dc.date.accessioned2023-07-15T00:14:52Z-
dc.date.available2023-07-15T00:14:52Z-
dc.date.issued2019-
dc.citation.volume11pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.1177/1759091419850983pt_BR
dc.identifier.issn1759-0914pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56350-
dc.description.resumoAbstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) member of the Flaviviridae family, which has been associated with the development of the congenital Zika syndrome (CZS). RNA viruses, such as flaviviruses, have been reported to exert a profound impact on host microRNAs (miRNAs). Cellular miRNAs modulated by ZIKV may help identify cellular pathways of relevance to pathogenesis. Here, we screened 754 human cellular miRNAs modulated by ZIKV infection (Brazilian PE strain) in a neuroblastoma cell line. Seven miRNAs (miR-99a*, miR-126*, miR-190b, miR-361-3p, miR-522-3p, miR-299-5p, and miR1267) were downregulated during ZIKV infection, while miR-145 was upregulated. Furthermore, 11 miRNAs were exclusively expressed in ZIKV-infected (miR-148a, miR-342-5p, miR-598, and miR-708-3p) or mock cells (miR-208, miR-329, miR432-5p, miR-488, miR-518b, miR-520g, and miR-767-5p). Furthermore, in silico analysis indicated that some central nervous system, cellular migration, and adhesion function-related biological processes were overrepresented in the list of target genes of the miRNAs regulated in ZIKV-infected cells, especially for miR-145 and miR-148a. The induction of miR-145 and miR-148a was confirmed in postmortem brain samples from stillborn with severe CZS. Finally, we determined the expression regulation of microcephaly related genes through RNA interference pathway caused by ZIKV directly on neuron cells.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofASN Neuropt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectmiRNAspt_BR
dc.subjectMicrocephalypt_BR
dc.subjectNeuroblastomapt_BR
dc.subjectPostmortem brain autopsiespt_BR
dc.subjectZikapt_BR
dc.subject.otherRetinoblastomapt_BR
dc.subject.otherVírus da Zikapt_BR
dc.subject.otherMicrocefaliapt_BR
dc.titleMicroRNAs 145 and 148a are upregulated during congenital Zika Virus Infectionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.sagepub.com/doi/10.1177/1759091419850983pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9381-385Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2193-2224pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0570-750Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2801-1786pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8663-3364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0723-3873pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9107-6865pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9172-1951pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9570-8244pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1407-3414pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7640-1463pt_BR
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