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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56355
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dc.creatorLívia Sacchettopt_BR
dc.creatorRodolfo German Antonelli Vidal Stumpppt_BR
dc.creatorAlaine Izabela Alves Pradopt_BR
dc.creatorAdriano Pereira Pagliapt_BR
dc.creatorFernando Araújo Perinipt_BR
dc.creatorMaurício Lacerda Nogueirapt_BR
dc.creatorErna Geessien Kroonpt_BR
dc.creatorBenoit de Thoisypt_BR
dc.creatorGiliane de Souza Trindadept_BR
dc.creatorBetânia Paiva Drumondpt_BR
dc.creatorNatalia Ingrid Oliveira Silvapt_BR
dc.creatorIzabela Maurício de Rezendept_BR
dc.creatorMatheus Soares Arrudapt_BR
dc.creatorThais Alkifeles Costapt_BR
dc.creatorÉrica Munhoz de Mellopt_BR
dc.creatorGabriela Fernanda Garcia Oliveirapt_BR
dc.creatorPedro Augusto Alvespt_BR
dc.creatorVítor Emídio de Mendonçapt_BR
dc.date.accessioned2023-07-15T00:17:40Z-
dc.date.available2023-07-15T00:17:40Z-
dc.date.issued2020-10-05-
dc.citation.volume14pt_BR
dc.citation.issue10pt_BR
dc.citation.spagee0008658pt_BR
dc.citation.epage16pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0008658pt_BR
dc.identifier.issn1935-2735pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56355-
dc.description.resumoBackground From the end of 2016 until the beginning of 2019, Brazil faced a massive sylvatic yellow fever (YF) outbreak. The 2016–2019 YF epidemics affected densely populated areas, especially the Southeast region, causing thousands of deaths of humans and non-human primates (NHP). Methodology/Principal findings We conducted a molecular investigation of yellow fever virus (YFV) RNA in 781 NHP carcasses collected in the urban, urban-rural interface, and rural areas of Minas Gerais state, from January 2017 to December 2018. Samples were analyzed according to the period of sampling, NHP genera, sampling areas, and sampling areas/NHP genera to compare the proportions of YFV-positive carcasses and the estimated YFV genomic loads. YFV infection was confirmed in 38.1% of NHP carcasses (including specimens of the genera Alouatta, Callicebus, Callithrix, and Sapajus), from the urban, urban-rural interface, and rural areas. YFV RNA detection was positively associated with epidemic periods (especially from December to March) and the rural environment. Higher median viral genomic loads (one million times) were estimated in carcasses collected in rural areas compared to urban ones. Conclusions/Significance The results showed the wide occurrence of YF in Minas Gerais in epidemic and non-epidemic periods. According to the sylvatic pattern of YF, a gradient of viral dissemination from rural towards urban areas was observed. A high YF positivity was observed for NHP carcasses collected in urban areas with a widespread occurrence in 67 municipalities of Minas Gerais, including large urban centers. Although there was no documented case of urban/Aedes YFV transmission to humans in Brazil during the 2016–2019 outbreaks, YFV-infected NHP in urban areas with high infestation by Aedes aegypti poses risks for YFV urban/Aedes transmission and urbanization.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE ZOOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLoS Neglected Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectYellow Fever viruspt_BR
dc.subjectYellow Feverpt_BR
dc.subjectSurveillancept_BR
dc.subject.otherFebre Amarelapt_BR
dc.subject.otherFebre amarela - Vacinapt_BR
dc.titleNeighbor danger: Yellow fever virus epizootics in urban and urban-rural transition areas of Minas Gerais state, during 2017-2018 yellow fever outbreaks in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008658pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4336-9284pt_BR
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