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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56423
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dc.creatorAna Luiza Chaves Valadãopt_BR
dc.creatorPaulo Damascopt_BR
dc.creatorGabriel Gonçalvespt_BR
dc.creatorRui Manuel Reispt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorCleonice Alves de Melo Bentopt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorPaula Pezzutopt_BR
dc.creatorViviane A. Oliveira Silvapt_BR
dc.creatorBarbara Simonson Gonçalvespt_BR
dc.creatorÁtila Duque Rossipt_BR
dc.creatorRodrigo Delvecchio da Cunhapt_BR
dc.creatorAntonio Carlos Sianipt_BR
dc.creatorJoão Batista de Freitas Tostespt_BR
dc.creatorMarcelo Trovópt_BR
dc.date.accessioned2023-07-17T18:06:17Z-
dc.date.available2023-07-17T18:06:17Z-
dc.date.issued2018-
dc.citation.volume13pt_BR
dc.citation.issue11pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0207664pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56423-
dc.description.resumoEuphorbia umbellata (E. umbellata) belongs to Euphorbiaceae family, popularly known as Janauba, and its latex contains a combination of phorbol esters with biological activities described to different cellular protein kinase C (PKC) isoforms. Here, we identified deoxi-phorbol esters present in E. umbellata latex alcoholic extract that are able to increase HIV transcription and reactivate virus from latency models. This activity is probably mediated by NF-kB activation followed by nuclear translocation and binding to the HIV LTR promoter. In addition, E. umbellata latex extract induced the production of pro inflammatory cytokines in vitro in human PBMC cultures. This latex extract also activates latent virus in human PBMCs isolated from HIV positive patients as well as latent SIV in non-human primate primary CD4+ T lymphocytes. Together, these results indicate that the phorbol esters present in E. umbellata latex are promising candidate compounds for future clinical trials for shock and kill therapies to promote HIV cure and eradication.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS ONEpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectEuphorbia umbellatapt_BR
dc.subjectHIV infectionpt_BR
dc.subjectLatex extractpt_BR
dc.subject.otherEuforbiaceapt_BR
dc.subject.otherInfecções por HIVpt_BR
dc.subject.otherLatexpt_BR
dc.titleReactivation of latent HIV-1 in vitro using an ethanolic extract from Euphorbia umbellata (Euphorbiaceae) latexpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207664pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-9639-7940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9570-8244pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5919-5242pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9378-0418pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6235-8807pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2951-3964pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8108-2500pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0478-2332pt_BR
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