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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/56475
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Campo DCValorIdioma
dc.creatorJoão Luís Vieira Monteirode Barrospt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorHaitham Salempt_BR
dc.creatorNatalia Pessoa Rochapt_BR
dc.creatorArthur Melo e Kummerpt_BR
dc.creatorOlaoluwa o. Okusagapt_BR
dc.creatorJair c. Soarespt_BR
dc.creatorAntonio Lucio Teixeirapt_BR
dc.date.accessioned2023-07-17T19:38:11Z-
dc.date.available2023-07-17T19:38:11Z-
dc.date.issued2017-11-17-
dc.citation.volume209pt_BR
dc.citation.issue2017pt_BR
dc.citation.spage59pt_BR
dc.citation.epage65pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jad.2016.11.016pt_BR
dc.identifier.issn01650327pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56475-
dc.description.resumoBackground: The relationship between Toxoplasma gondii infection and the development of bipolar disorder (BD) has long been investigated, yet to date it is still poorly understood and documented. The aim of this review is to derive a summary estimate of the strength of the association between infection with T. gondii and BD from the available published studies.Methods: A systematic review was performed using PubMed, LILACS, PsycINFO, and Embase databases.Studies which included a proportion of seropositive BD patients and controls were further examined in a metaanalysis.Results: One hundred eighteen citations were initially retrieved. Thirteen studies were included in our systematic review. Eight out of these thirteen studies were included in our meta-analysis. Statistical analyses showed that T. gondii infection is associated with with BD (OR=1.26).Limitations: Small sample size was the major limitation among the studies that carried out serological analyses.In addition, the available studies did not have enough information on disease status/severity or type of bipolar disorder. Also, it was not possible to analyze pregnancy status or perinatal infection. Future studies addressing the aforementioned topics are clearly needed.Conclusions: Despite heterogeneous results, patients with BD are more likely to be infected by T. gondii than controls. Early T. gondii infection might predispose the development of BD. T.gondii infection is becoming clinically relevant in psychiatric disorders and future mechanistic studies are required to elucidate the underlying pathophysiological mechanisms.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Affective Disorders-
dc.rightsAcesso Restritopt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectToxoplasma gondiipt_BR
dc.subjectImmunologypt_BR
dc.subjectInflammationpt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherToxoplasmapt_BR
dc.titleIs there any association between toxoplasma gondii infection and bipolar disorder? a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0165032716305614?via%3Dihubpt_BR
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