1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56504
Full metadata record
DC FieldValueLanguage
dc.creatorAlysson Vinícius Bragapt_BR
dc.creatorIvo Souza Ferraz Melopt_BR
dc.creatorArmando da Silva Cunha Júniorpt_BR
dc.creatorIsabela da Costa Césarpt_BR
dc.creatorMarília Oliveira Fonseca Goulartpt_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorRenes Resende Machadopt_BR
dc.creatorRoger Ryuler Lisboa da Silvapt_BR
dc.creatorIanny Bandeira Rodriguespt_BR
dc.creatorGabriel Vitor de Lima Marquespt_BR
dc.creatorAndre Felippe de Almeida Xavierpt_BR
dc.creatorAnastacio Boanept_BR
dc.creatorMayara Rodrigues Brandão de Paivapt_BR
dc.creatorPedro Henrique Cavalcanti Francopt_BR
dc.creatorFelipe Fernandes Rodriguespt_BR
dc.date.accessioned2023-07-17T20:30:09Z-
dc.date.available2023-07-17T20:30:09Z-
dc.date.issued2021-01-
dc.citation.volume133pt_BR
dc.citation.spage110913pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2020.110913pt_BR
dc.identifier.issn0753-3322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56504-
dc.description.resumoConsidering the many biological activities of nitric oxide (NO), some lines of research focused on the modulation of these activities through the provision of this mediator by designing and synthesizing compounds coupled with an NO donor group. Thus, the objectives of the present study were to carry out an electrochemical investigation of the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid (1) and evaluate its activities and putative mechanisms in experimental models of pain and inflammation. Voltammetric studies performed in aprotic medium (mimetic of membranes) showed important electrochemical reduction mechanisms: nitroaromatic reduction, self-protonation, and finally reductive elimination, which leads to nitrate release. Systemic admin istration of the nitrooxy compound (1) inhibited the nociceptive response induced by heat and the tactile hypersensitivity and paw edema induced by carrageenan in mice. The activities in the models of inflammatory pain and edema were associated with reduced neutrophil recruitment and production of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, tumor necrosis factor-α and CXCL-1, and increased production of IL-10. Concluding, electrochemical analysis revealed unequivocally that electron transfer at the nitro group of the nitrooxy com pound (1) results in the cleavage of the organic nitrate, potentially resulting in the generation of NO. This electrochemical mechanism may be compared to a biochemical electron-transfer mediated nitrate release that, by appropriate in vivo bioreduction (enzymatic or not) would lead to NO production. Compound (1) exhibits activities in models of inflammatory pain and edema that may be due to reduced recruitment of neutrophils and production of inflammatory cytokines and increased production of IL-10. These results reinforce the interest in the investigation of NO donor compounds as candidates for analgesic and anti-inflammatory drugs.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentFARMACIA - FACULDADE DE FARMACIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFarmáciapt_BR
dc.subjectQuímicapt_BR
dc.subject.otherFarmáciapt_BR
dc.subject.otherQuímicapt_BR
dc.titleElectrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332220311057?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1349-9413pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Electrochemical evidence of nitrate release from the nitrooxy compound 4-((nitrooxy) methyl)-3-nitrobenzoic acid and its antinociceptive and anti-inflammatory activities in mice.pdf39.36 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.