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http://hdl.handle.net/1843/56549| Type: | Artigo de Periódico |
| Title: | Decreased percentage of cd4+ lymphocytes expressing chemokine receptors in bipolar disorder |
| Authors: | Izabela Guimarães Barbosa Antonio l. Teixeira Natalia p. Rocha Erica l. Vieira Mehmet a. Camkurt Rodrigo b. Huguet Fabio t. l. Guimarães Gustavo e. de Brito-melo Vanessa a. Mendonça Moises e. Bauer |
| Abstract: | Objective:Although accumulating evidence supports the hypothesis that immune/inflammatory mechanisms are associated with the pathophysiology of bipolar disorder (BD), data about the profile of chemokines (chemotactic cytokines) and chemokine receptors are still scarce. The current study was designed to evaluate the expression of chemokine receptors on lymphocytes of patients with BD in comparison with controls.Methods:Thirty-three patients with type I BD (N = 21 in euthymia; N = 6 in mania/hypomania; N = 6 in depression) and 22 age- and sex-matched controls were subjected to clinical evaluation and peripheral blood draw. The expression of chemokine receptors CCR3, CCR5, CXCR4, and CXCR3 on CD4+ and CD8+ lymphocytes was assessed by flow cytometry.Results: Patients with BD had decreased percentage of CD4+CXCR3+ (p = 0.024), CD4+CCR3+ (p = 0.042), and CD4+CCR5+ (0.013) lymphocytes in comparison with controls. The percentage of both CD4+ and CD8+ lymphocytes expressing the chemokine receptor CXCR4 was similar in patients with BD and controls. Likewise, the percentages of CD8+CXCR3+, CD8+CCR3+, and CD8+CCR5+ lymphocytes were similar in patients with BD and controls.Conclusion:Our findings reinforce the hypothesis that immune pathways, especially involving CD4+ lymphocytes, are involved in the physiopathology of BD. |
| Subject: | Transtorno bipolar Receptores de Quimiocinas Psiconeuroimunologia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Restrito |
| URI: | http://hdl.handle.net/1843/56549 |
| Issue Date: | 14-Mar-2019 |
| metadata.dc.url.externa: | https://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/abs/decreased-percentage-of-cd4-lymphocytes-expressing-chemokine-receptors-in-bipolar-disorder/08681909CC64CC29567F9C4BC5456600 |
| metadata.dc.relation.ispartof: | Acta Neuropsychiatrica |
| Appears in Collections: | Artigo de Periódico |
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