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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56589
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dc.creatorRenata Cristina Rezende Macedo do Nascimentopt_BR
dc.creatorMarion Benniept_BR
dc.creatorAmanj Kurdipt_BR
dc.creatorTanja Muellerpt_BR
dc.creatorBrian Godmanpt_BR
dc.creatorSean Macbride Stewartpt_BR
dc.creatorSimon Hurdingpt_BR
dc.creatorFrancisco Assis Acurciopt_BR
dc.creatorAugusto Afonso Guerra Júniorpt_BR
dc.creatorJuliana Alvares Teodoropt_BR
dc.creatorAlec Mortonpt_BR
dc.date.accessioned2023-07-18T16:49:21Z-
dc.date.available2023-07-18T16:49:21Z-
dc.date.issued2020-
dc.citation.spage2349pt_BR
dc.citation.epage2361pt_BR
dc.identifier.doihttps://doi.org/10.1111/bcp.14333pt_BR
dc.identifier.issn0306-5251pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56589-
dc.description.resumoAim: To assess associations between statin intensity and adherence, persistence and discontinuation of statin therapy in Scotland. Method: Retrospective cohort study, using linked electronic health records covering a period from January 2009 to December 2016. The study cohort included adult patients (≥18 years) newly initiating statins within Greater Glasgow and Clyde, Scotland. Study outcomes comprised adherence, discontinuation and persistence to treatment, stratified by three exposure groups (high, moderate and low intensity). Discontinuation and persistence were calculated using the refill-gap and anniversary methods, respectively. Proportion of days covered (PDC) was used as a proxy for adherence. Kaplan-Meier survival curves and Cox proportional hazard models were used to evaluate discontinuation, and associations between adherence/persistence and statin intensity were assessed using logistic regression. Results: A total of 73 716 patients with a mean age of 61.4 ± 12.6 years were included; the majority (88.3%) received moderate intensity statins. Discontinuation rates differed between intensity levels, with high-intensity patients less likely to discontinue treatment compared to those on moderate intensity (prior cardiovascular disease [CVD]: HR 0.43 [95% CI 0.34-0.55]; no prior CVD: 0.80 [0.74-0.86]). Persistence declined over time, and high-intensity patients had the highest persistence rates. Overall, 52.6% of patients were adherent to treatment (PDC ≥ 80%), but adherence was considerably higher among high-intensity patients (63.7%). Conclusion: High-intensity statins were associated with better persistence and adherence to treatment, but overall long-term persistence and adherence remain a challenge, particularly among patients without prior CVD. This needs addressingpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBritish Journal of Clinical Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCardiovascular diseasept_BR
dc.subjectDrug utilisationpt_BR
dc.subjectHigh-intensity therapypt_BR
dc.subjectMedication adherencept_BR
dc.subjectScotlandpt_BR
dc.subjectStatinspt_BR
dc.subject.otherSistema cardiovascular - Doençaspt_BR
dc.subject.otherEscóciapt_BR
dc.subject.otherEstatinas (Agentes cardiovasculares)pt_BR
dc.titleReal-world evaluation of the impact of statin intensity on adherence and persistence to therapy: a scottish population-based studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14333pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6410-9716pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4046-629Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5036-1988pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0418-4789pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6539-6972pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2553-5939pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5880-5261pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5256-0577pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0210-0721pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3803-8517pt_BR
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