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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56633
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dc.creatorRafael Coelho Magalhãespt_BR
dc.creatorJanaina Matos Moreirapt_BR
dc.creatorÉrica Leandro Marciano Vieirapt_BR
dc.creatorNatália Pessoa Rochapt_BR
dc.creatorDébora Marques Mirandapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.date.accessioned2023-07-18T20:19:43Z-
dc.date.available2023-07-18T20:19:43Z-
dc.date.issued2017-05-02-
dc.citation.volume2017pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.1155/2017/8201423pt_BR
dc.identifier.issn0962-9351pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56633-
dc.description.resumoObjectives. To evaluate the association between inflammatory biomarkers, neurotrophic factors, birth conditions, and the presence of motor development abnormalities in preterm neonates. Methods. Plasma and urinary levels of cytokines (IL-1β, IL-6, IL-10, TNF, and IL-12p70), chemokines (CXCL8/IL-8, CCL2/MCP-1, CCL5/RANTES, CXCL10/IP-10, and CXCL9/MIG), and neurotrophic factors (BDNF and GDNF) were evaluated in 40 preterm neonates born between 28 and 32 incomplete weeks of gestation, at four distinct time points: at birth (umbilical cord blood) (T0), at 48 (T1), at 72 hours (T2), and at 3 weeks after birth (T3). Biomarkers levels were compared between different time points and then associated with Test of Infant Motor Performance (TIMP) percentiles. Results. Maternal age, plasma, and urinary concentrations of inflammatory molecules and neurotrophic factors were significantly different between groups with normal versus lower than expected motor development. Higher levels of GDNF were found in the group with lower than expected motor development, while IL-1β and CXCL8/IL-8 values were higher in the group with typical motor development. Conclusion. Measurements of cytokines and neurotrophic factors in spot urine may be useful in the follow-up of motor development in preterm neonates.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONALpt_BR
dc.publisher.departmentEEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMediators of Inflammationpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectRecém-Nascidopt_BR
dc.subjectUrinapt_BR
dc.subject.otherRecém-Nascidopt_BR
dc.subject.otherUrinapt_BR
dc.titleUrinary Levels of IL-1β and GDNF in Preterm Neonates as Potential Biomarkers of Motor Development: A Prospective Studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/mi/2017/8201423/pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-4147-5614pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-2616-8082pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-9222-3882pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7081-8401pt_BR
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