1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56636
Full metadata record
DC FieldValueLanguage
dc.creatorLuiz Alexandre Viana Magnopt_BR
dc.creatorAlexander Birbrairpt_BR
dc.creatorDébora Marques Mirandapt_BR
dc.creatorMarco Aurélio Romano-silvapt_BR
dc.creatorHelia Tenza-ferrerpt_BR
dc.creatorMélcar Collodettipt_BR
dc.creatorMatheus Felipe Guimarães Aguiarpt_BR
dc.creatorAna Paula Carneiro Rodriguespt_BR
dc.creatorRodrigo Souza da Silvapt_BR
dc.creatorJoice do Prado Silvapt_BR
dc.creatorNycolle Ferreira Nicolaupt_BR
dc.creatorDaniela Valadão Freitas Rosapt_BR
dc.date.accessioned2023-07-18T20:23:17Z-
dc.date.available2023-07-18T20:23:17Z-
dc.date.issued2019-04-24-
dc.citation.volume39pt_BR
dc.citation.issue17pt_BR
dc.citation.spage3234pt_BR
dc.citation.epage3248pt_BR
dc.identifier.doihttps://doi.org/10.1523/JNEUROSCI.2277-18.2019pt_BR
dc.identifier.issn0270-6474pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56636-
dc.description.resumoNeuromodulation of deep brain structures (deep brain stimulation)isthe current surgical procedurefortreatment of Parkinson’s disease (PD). Less studied is the stimulation of cortical motor areas to treat PD symptoms, although also known to alleviate motor disturbances in PD.We were ableto showthat optogenetic activation of secondary (M2) motor cortex improves motorfunctions in dopamine-depleted male mice. The stimulated M2 cortex harbors glutamatergic pyramidal neurons that project to subcortical structures, critically involved inmotor control, andmakes synaptic contactswithdopaminergic neurons. Strikingly, optogenetic activation ofM2 neurons or axonsinto the dorsomedial striatum increases striatal levels of dopamine and evokes locomotor activity. We found that dopamine neurotransmission sensitizes the locomotor behavior elicited by activation of M2 neurons. Furthermore, combination of intranigral infusion of glutamatergic antagonists and circuit specific optogenetic stimulation revealed that behavioral response depended on the activity of M2 neurons projecting to SNc. Interestingly, repeated M2 stimulation combined with L-DOPA treatment produced an unanticipated improvement in working memory performance, which was absent in control mice under L-DOPA treatment only. Therefore, the M2-basal ganglia circuit is critical for the assembly of the motor and cognitive function, and this study demonstrates a therapeutic mechanism for cortical stimulation in PD that involves recruitment of long-range glutamatergic projection neurons.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Journal of Neurosciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBrain stimulationpt_BR
dc.subjectCognitionpt_BR
dc.subjectMovementpt_BR
dc.subjectOptogeneticspt_BR
dc.subjectParkinson’s disorderpt_BR
dc.subjectPrefrontal cortexpt_BR
dc.subject.otherEncéfalopt_BR
dc.subject.otherCogniçãopt_BR
dc.subject.otherMovimentopt_BR
dc.subject.otherOptogenéticapt_BR
dc.subject.otherCórtex Pré-Frontalpt_BR
dc.titleOptogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction in a Mouse Model of Parkinson’s Diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.jneurosci.org/content/39/17/3234pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7081-8401pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Optogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction in a Mouse Model of Parkinson’s Disease.pdf4.93 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.