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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56691
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dc.creatorLuiz Claudio Romanellipt_BR
dc.creatorMarco Aurelio Romano Silvapt_BR
dc.creatorRodrigo Nicolatopt_BR
dc.creatorDébora M. Mirandapt_BR
dc.creatorAnna Barbara Carneiro Proiettipt_BR
dc.creatorMarcelo Mamedept_BR
dc.creatorHérika Vasconcelospt_BR
dc.creatorMarina Martinspt_BR
dc.creatorAnísia S. D. Ferreirapt_BR
dc.creatorDaniela Rosapt_BR
dc.creatorJonas de Paulapt_BR
dc.date.accessioned2023-07-19T16:49:23Z-
dc.date.available2023-07-19T16:49:23Z-
dc.date.issued2018-
dc.citation.volume12pt_BR
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage19pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0006720pt_BR
dc.identifier.issn1935-2735pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56691-
dc.description.resumoBackground HTLV-1 infection is endemic in Brazil. About 1 to 2% of the Brazilian population is estimated to be infected, but most infected HTLV-1 individuals do not know about their own infection, which favors the continuity of sexual and vertical virus transmission. In addition, HTLV-1 associated central nervous system diseases and their pathophysiologic mechanisms are not fully understood. This study aimed to evaluate the correlation of spinal cord metabolism, viral and inflammatory profiles with features of neurological presentation in HTLV-1 infected individuals. Methodology This is a cross-sectional study of a cohort including 48 HTLV-1 infected individuals clinically classified as asymptomatic-AG (N = 21), symptomatic-SG (N = 11) and HAM/TSP-HG (N = 16) and a nested case-control study with HTLV-1 infected individuals-HIG (N = 48) and HTLV-1 non infected controls-CG (N = 30) that had their spinal cord analysed by Positron Emission Tomography with 18F-Fluordeoxyglucose (18F-FDG PET/CT). HTLV-1 infected individuals had 18F-FDG PET/CT results analyzed with clinical and demographic data, proviral load, cytokines and chemokines in the blood and cerebrospinal fluid (CSF). Principal Findings 18F-FDG PET/CT showed hypometabolism in the thoracic spinal cord in HTLV-1 infected individuals. The method had an accuracy of 94.4% to identify HAM/TSP. A greater involvement of the thoracic spinal cord was observed, although hypometabolism was also observed in the cervical spinal cord segment in HTLV-1 infected individuals. Individuals with HAM/TSP showed a pro-inflammatory profile in comparison to asymptomatic and symptomatic groups, with a higher level of Interferon-inducible T-cell alpha chemoattractant (ITAC/CXCL11), IL-6, IL-12p70 in the plasma; and ITAC, IL-4, IL-5, IL-8 (CXCL8) and TNF-alpha in the CSF. Using regression, thoracic spinal cord SUV (standardized uptake value) and CSF ITAC level were identified as the HAM/TSP predictors in the multivariate model. Conclusions 18F-FDG PET/CT imaging showed spinal cord hypometabolism in most HTLV-1 infected individuals, even in the asymptomatic HTLV-1 group. Thoracic spinal cord hypometabolism and CSF-ITAC levels were identified predictors of HAM/TSP.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEMpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS Neglected Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHTLV-1pt_BR
dc.subjectInfection is endemicpt_BR
dc.subject.otherEndemias - Brasilpt_BR
dc.subject.otherHTLV-I (Virus)pt_BR
dc.titleSpinal cord hypometabolism associated with infection by human T-cell lymphotropic virus type 1(HTLV-1)pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006720pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7936-0687pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6558-4639pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1585-7720pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7081-8401pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4302-5817pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5818-0954pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6292-1716pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2506-8450pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8868-7895pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5530-2346pt_BR
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