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http://hdl.handle.net/1843/56692| Type: | Artigo de Periódico |
| Title: | A genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation |
| Authors: | Nathália Gualberto Souza e Silva Eduardo S. Nicolau Kate Hoy Ziarih Hawi Mark Bellgrove Débora Miranda Marco Aurelio Romano Silva Paul Fitzgerald |
| Abstract: | Effective in treatment-resistant depression (TRD), repetitive transcranial magnetic stimulation (rTMS) presents a remission rate between 30% and 40%. Although genetics could be one potential source of inter-individual variability in rTMS responsiveness, few studies have sought to identify possible genetic basis of rTMS response [1,2]. Therefore, we used an extreme-phenotype design in which we compared genome-wide allelic variation between rigorously defined rTMS responders and non-responders. A total of 99 TRD patients provided informed consent and this study was approved by the Human Research and Ethics Committee of the Alfred Hospital. All were submitted to a rTMS protocol and completed at least 18 sessions of 10 Hz at left dorsolateral prefrontal cortex (DLPFC). Clinical outcomes (responder or non-responder) were determined based on scores on the Montgomery Asberg Depression Rating Scale (MADRS). |
| Subject: | Aspectos genéticos Depressão mental - Tratamento |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.brs.2020.04.019 |
| URI: | http://hdl.handle.net/1843/56692 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.brainstimjrnl.com/article/S1935-861X(20)30098-X/fulltext#%20 |
| metadata.dc.relation.ispartof: | Brain Simulation |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A genetic profile of refractory individuals with major depressive disorder and their responsiveness to transcranial magnetic stimulation.pdf | 127.17 kB | Adobe PDF | View/Open |
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