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Tipo:	Artigo de Periódico
Título:	Impact of overweight in mens with family history of hypertension: early heart rate variability and oxidative stress disarrangements
Autor(es):	Ariane Viana Danielle da Silva Dias Mario Cesar Nascimento Fernando Dos Santos Fernanda de Cordoba Lanza Maria Cláudia Irigoyen Kátia de Angelis
Resumo:	Aim. To evaluate cardiovascular, autonomic, and oxidative stress markers in eutrophic and overweight offspring of hypertensive parents comparing them to eutrophic and overweight offspring of normotensive parents. Methods. We conducted a cross sectional study. We selected 71 male and sedentary subjects, divided into 4 groups: eutrophic group with a negative family history of hypertension (EH-, n =18) or positive family history of hypertension (EH+, n =17), overweight group with a negative family history of hypertension (OH-, n =19) or a positive family history of hypertension (OH+, n =17), and aged between 18 and 35 years. Results. Blood glucose was higher in the OH+ group when compared to other groups. Diastolic blood pressure was increased in OH- and OH+ groups when compared to eutrophic groups. Regarding the HRV, the LF abs was higher in OH- and OH+ groups when compared to the EH- group. LF/HF values were higher in EH+ and OH+ groups when compared to the EH and OH- groups. As to oxidative stress and the metabolism of nitric oxide, we observed an increase in hydrogen peroxide and nitrite levels in the OH+ group, and in the NADPH oxidase in OH- and OH+ groups when compared to the other groups. Conclusion. Our findings demonstrate that the overweight group with a family history of hypertension presented all the dysfunctions observed in isolation from these risk factors. We observed an exacerbation of cardiac sympathetic modulation and early prooxidants increase, which may be associated with target organ damage and cardiovascular risk in this population.
Assunto:	Sobrepeso Hipertensão
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	EEF - DEPARTAMENTO DE FISIOTERAPIA EEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONAL
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1155/2020/3049831
URI:	http://hdl.handle.net/1843/56719
Data do documento:	31-Jul-2020
metadata.dc.url.externa:	https://www.hindawi.com/journals/omcl/2020/3049831/
metadata.dc.relation.ispartof:	Oxidative Medicine and Cellular Longevity
Aparece nas coleções:	Artigo de Periódico

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