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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56740
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dc.creatorAna Luiza Lunardi Rochapt_BR
dc.creatorL. C. Fariapt_BR
dc.creatorT. C. M. Guimarãespt_BR
dc.creatorGiovanna Vieira Moreirapt_BR
dc.creatorA. L. Cândidopt_BR
dc.creatorC. A. Coutopt_BR
dc.creatorFernando Marcos dos Reispt_BR
dc.date.accessioned2023-07-19T18:12:27Z-
dc.date.available2023-07-19T18:12:27Z-
dc.date.issued2017-
dc.citation.volume40pt_BR
dc.citation.spage1279pt_BR
dc.citation.epage1288pt_BR
dc.identifier.doihttps://doi.org/10.1007/s40618-017-0708-9pt_BR
dc.identifier.issn1720-8386pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56740-
dc.description.resumoPurpose Non-alcoholic fatty liver disease (NAFLD) is an insidious pathologic condition that can manifest from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. Like the polycystic ovary syndrome (PCOS), NAFLD is associated with obesity, diabetes mellitus, insulin resistance and metabolic syndrome. PCOS women have an increased risk of NAFLD, but it is debatable which features of PCOS, either specific (androgen excess) or unspecific (metabolic derangements) affect the NAFLD risk. Methods We performed a systematic review and meta-analysis of studies that addressed the association of PCOS and NAFLD. We selected 17 studies published between 2007 and 2017 that included 2734 PCOS patients and 2561 controls of similar age and body mass index (BMI). Results PCOS patients have increased prevalence of NAFLD (odds ratio 2.54, 95% confidence interval 2.19–2.95). PCOS women with hyperandrogenism (classic phenotype) have a higher prevalence of NAFLD compared to women with PCOS without hyperandrogenism, even after correction for confounding variables. Among women with PCOS, those with NAFLD have higher serum total testosterone (mean difference 0.40 nmol/L, 95% CI 0.29–0.50 nmol/L) and free androgen index (mean difference 4.46, 95% CI 3.53–5.39) than those without NAFLD. The studies that used multivariate analysis controlling for age, BMI, triglycerides, and insulin resistance index confirmed that serum androgens are independent predictors of NAFLD in women with PCOS. Conclusion The prevalence of NAFLD is increased in women with PCOS and the presence of NAFLD is associated with high serum androgen levels, in addition to obesity and insulin resistance.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Endocrinological Investigationpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectNon-alcoholic fatty liver disease (NAFLD)pt_BR
dc.subjectObesitypt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectInsulin resistancept_BR
dc.subjectMetabolic syndromept_BR
dc.subject.otherObesidadept_BR
dc.subject.otherDiabetespt_BR
dc.subject.otherResistência à insulinapt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.titleNon-alcoholic fatty liver disease in premenopausal women with polycystic ovary syndrome: a systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s40618-017-0708-9pt_BR
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