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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56766
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dc.creatorCamila Silva Peres Cancelapt_BR
dc.creatorJuliana Godoy Assumpçãopt_BR
dc.creatorFrancisco Danilo Ferreira de Paulapt_BR
dc.creatorMitiko Muraopt_BR
dc.creatorMarcos Borato Vianapt_BR
dc.creatorBenigna Maria de Oliveirapt_BR
dc.date.accessioned2023-07-19T19:52:31Z-
dc.date.available2023-07-19T19:52:31Z-
dc.date.issued2018-
dc.citation.volume64pt_BR
dc.citation.spage205pt_BR
dc.citation.epage209pt_BR
dc.identifier.doi10.7754/clin.lab.2017.170622pt_BR
dc.identifier.issn14336510pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56766-
dc.description.resumoBackground: Cytological analysis of the cerebrospinal fluid (CSF) remains the most widely used method for diagnosing central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL). This study aimed at evaluating the use of polymerase chain reaction (PCR), in comparison to other methods, for the assessment of the presence of blast cells in the CSF at the time of diagnosis of ALL. Methods: This was a prospective, single-centre, study enrolling all patients up to the age of 18 years who were admitted to a university hospital between November 2011 and November 2014 with a diagnosis of ALL and from whom it was possible to draw a sufficient amount of CSF for analysis by conventional cytology (CT), immunophenotyping (IMP), and PCR.Results: A total of 46 CSF samples from 44 ALL pediatric patients were included. CT was performed in all samples, IMP in 44, and PCR in 34. Thirteen (28.2%) samples showed positive results: two by CT, four by IMP, four by PCR, and three by both IMP and PCR.Conclusions: The results of this study showed that PCR should be considered a complementary method for the evaluation of the CSF in ALL patients at diagnosis.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Laboratory-
dc.rightsAcesso Restritopt_BR
dc.subjectacute lymphoblastic leukemiapt_BR
dc.subjectcentral nervous systempt_BR
dc.subjectCerebrospinal fluidpt_BR
dc.subjectpolymerase chain reactionpt_BR
dc.subjectdiagnosispt_BR
dc.subject.otherLeucemia-Linfoma Linfoblástico de Células Precursoraspt_BR
dc.subject.otherVazamento de Líquido Cefalorraquidianopt_BR
dc.subject.otherLíquido Cefalorraquidianopt_BR
dc.subject.otherSistema Nervoso Centralpt_BR
dc.subject.otherReação em Cadeia da Polimerasept_BR
dc.subject.otherDiagnósticopt_BR
dc.titleUse of the polymerase chain reaction as a complementary method for the detection of central nervous system involvement in children and adolescents with acute lymphoblastic leukemiapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.clin-lab-publications.com/article/2622pt_BR
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