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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56767
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dc.creatorFlávia Patrícia Sena Teixeirasantospt_BR
dc.creatorBruno Ramos Nascimentopt_BR
dc.creatorDébora Cerqueira Calderaropt_BR
dc.creatorGilda Aparecida Ferreirapt_BR
dc.creatorHumberto Corrêa da Silva Filhopt_BR
dc.date.accessioned2023-07-19T20:13:11Z-
dc.date.available2023-07-19T20:13:11Z-
dc.date.issued2021-
dc.citation.volume27pt_BR
dc.citation.issue5pt_BR
dc.citation.spage206pt_BR
dc.citation.epage214pt_BR
dc.identifier.doi10.1097/rhu.0000000000001029pt_BR
dc.identifier.issn10761608pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56767-
dc.description.resumoObjective: The aim of this study was to access the prevalence of 19 neuropsychiatric syndromes in childhood-onset systemic lupus erythematosus (cSLE), as defined by the American College of Rheumatology(ACR) in 1999, by performing a systematic review and meta-analysis of relevant publications.Methods: A literature search from April 1999 to March 2018 identified studies investigating neuropsychiatric syndromes in cSLE patients, applying 1999 ACR Case Definitions, with a sample of at least 20 patients. Case reports, small case series, reviews, articles that did not use 1999 ACR case definitions, and those with adult SLE patients were excluded. The methodological quality of the studies was determined through the Loney quality assessment. Prevalence estimates with a 95% confidence interval were combined using random-effect (DerSimonian-Laird) models.Results: A total of 143 articles were identified and 9 were included. In a population of 1463 cSLE patients, 351 (29.9%) presented 869 neuropsy chiatric cSLE events (2.48 events/patient). The results for each syndrome were headache (52.2%), seizure disorders (48.6%), cognitive dysfunction (32.9%), mood disorder (28.3%), psychosis (22.7%), cerebrovascular disease (19.5%), acute confusional state (15.7%), movement disorder (9.4%), anx iety disorder (7.2%), aseptic meningitis (5.1%), mononeuropathy single/ multiplex (4.9%), myelopathy (4.2%), demyelinating syndrome (3.2%),cranial neuropathy (2.7%), polyneuropathy (2.6%), Guillain-Barré syndrome (2.5%), autonomic disorder (1.9%), plexopathy (1.3%), and myasthenia gravis (1.3%).Conclusions: Neuropsychiatric syndromes are prevalent among cSLE patients. The most prevalent were headaches, seizures, cognitive dysfunction, mood disorders, and psychosis. Determining the prevalence of each neuropsychiatric syndrome in cSLE may improve clinical awareness of these potentially fatal and disabling conditions.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTORpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJCR: Journal of Clinical Rheumatology-
dc.rightsAcesso Restritopt_BR
dc.subjectChildhoodpt_BR
dc.subjectNeuropsychiatricpt_BR
dc.subjectSystemic lupuspt_BR
dc.subjectMeta-analysispt_BR
dc.subject.otherLúpus Eritematoso Sistêmicopt_BR
dc.subject.otherMetanálisept_BR
dc.titleNeuropsychiatric syndromes in childhood-onset systemic lupus erythematosuspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/jclinrheum/Abstract/2021/08000/Neuropsychiatric_Syndromes_in_Childhood_Onset.7.aspxpt_BR
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