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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56795
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dc.creatorJôice Dias Corrêapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorDébora Cerqueira Calderaropt_BR
dc.creatorGilda Aparecida Ferreirapt_BR
dc.creatorSantuza Maria Souza Mendonçapt_BR
dc.creatorGabriel R. Fernandespt_BR
dc.creatorE. Xiaopt_BR
dc.creatorAntônio Lúcio Teixeirapt_BR
dc.creatorEugene J. Leyspt_BR
dc.creatorDana T. Gravespt_BR
dc.date.accessioned2023-07-20T20:58:35Z-
dc.date.available2023-07-20T20:58:35Z-
dc.date.issued2017-
dc.citation.volume5pt_BR
dc.citation.issue34pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1186/s40168-017-0252-zpt_BR
dc.identifier.issn20492618pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56795-
dc.description.resumoBackground: Periodontitis results from the interaction between a subgingival biofilm and host immune response.Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity.Methods: We evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing.Results: SLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis. Conclusions: SLE is associated with differences in the composition of the microbiota, independently of periodontal status.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTORpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMicrobiome-
dc.rightsAcesso Abertopt_BR
dc.subjectLupuspt_BR
dc.subjectOral microbiotapt_BR
dc.subjectPeriodontitispt_BR
dc.subjectCytokinept_BR
dc.subjectSubgingival dental plaquept_BR
dc.subjectIllumina sequencingpt_BR
dc.subject.otherLupuspt_BR
dc.subject.otherPeriodontitept_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherPlaca Dentáriapt_BR
dc.subject.otherSequenciamento de Nucleotídeos em Larga Escalapt_BR
dc.titleSubgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal statuspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0252-zpt_BR
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