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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56819
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dc.creatorLuan c v Alvespt_BR
dc.creatorIsabela Moreira Gondimpt_BR
dc.creatorLuanne f Ferreirapt_BR
dc.creatorTania Mara Guimaraespt_BR
dc.creatorVicente de Paula Coelho Peixoto Toledopt_BR
dc.creatorMaria Das Graças Carvalhopt_BR
dc.creatorFernanda Freire Campospt_BR
dc.creatorEdna Afonso Reispt_BR
dc.creatorGilda Aparecida Ferreirapt_BR
dc.creatorDebora Cerqueira Calderaropt_BR
dc.creatorJoana Starling de Carvalhopt_BR
dc.creatorPaulo m Paduapt_BR
dc.creatorWalter Batista Cicarinipt_BR
dc.date.accessioned2023-07-20T21:30:36Z-
dc.date.available2023-07-20T21:30:36Z-
dc.date.issued2019-08-30-
dc.citation.volume499pt_BR
dc.citation.issue2019pt_BR
dc.citation.spage16pt_BR
dc.citation.epage23pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.cca.2019.08.033pt_BR
dc.identifier.issn00098981pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56819-
dc.description.resumoBackground: Systemic Lupus Erythematosus (SLE) is an autoimmune, multisystemic disease. Currently diagnosis depends on complex criteria developed by the American College of Rheumatology. Moreover, the lack of specific biomarkers also challenges the diagnosis. Methods: Inflammatory biomarkers such as IL-8, IP-10, MIG, MIP-1α and RANTES were measured in serum samples from SLE patients and subjects in control groups (patients with other autoimmune diseases and healthy individuals). Forty-six SLE patients (22 patients with low activity, SLEDAI-2 K ≤ 4, 24 patients with moderate/ high activity, SLEDAI-2 K > 4), 42 patients with other autoimmune diseases (OAD group), and 8 healthy vo lunteers participated in this study. Results: MIG (p < .001) and RANTES (p < .001) concentrations in SLE patients and healthy controls, and IP-10 concentrations in SLE patients with different disease activities (low activity, p < .01, moderate/high activity, p < .05) differed significantly. IL-8 (p < .001) and MIP-1α (p < .001) concentrations in SLE patients differed from those in patients from the OAD group. IL-8 (p < .05), IP-10 (p < .01), MIG (p < .05), MIP-1α (p < .001), and RANTES (p < .05) were correlated with SLE activity; their concentrations in SLE patients with low and moderate/high activity differed significantly. Conclusions: Given the findings of this study, one can envision the possibility of future use of some of these cytokines to assist in the screening of SLE patients, or even in monitoring disease activity.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinica Chimica Acta-
dc.rightsAcesso Abertopt_BR
dc.subjectSystemic Lupus Erythematosuspt_BR
dc.subjectBiomarkerspt_BR
dc.subjectdiagnosticopt_BR
dc.subject.otherLúpus Eritematoso Sistêmicopt_BR
dc.subject.otherBiomarcadorespt_BR
dc.titleEvaluation of potential biomarkers for the diagnosis and monitoring of Systemic Lupus Erythematosus using the Cytometric Beads Array (CBA)pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0009898119320285?via%3Dihubpt_BR
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