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Type:	Artigo de Periódico
Title:	Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
Authors:	Jôice Diascorrêa Antônio Lúcio Teixeira Chiranjit Mukherjee Eugene j. Leys Tarcília Aparecida da Silva Dana t. Graves Gabriel r. Fernandes Débora Cerqueira Calderaro Santuza Maria Souza Mendonça Janine Mayra Silva Mayra Laino Albiero Fernando q. Cunha e. Xiao Gilda Aparecida Ferreira
Abstract:	Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.
Subject:	Disbiose Artrite reumatóide Periodontite Citocina
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE APARELHO LOCOMOTOR MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1038/s41598-019-44674-6
URI:	http://hdl.handle.net/1843/56823
Issue Date:	10-Jun-2019
metadata.dc.url.externa:	https://www.nature.com/articles/s41598-019-44674-6
metadata.dc.relation.ispartof:	scientific reports
Appears in Collections:	Artigo de Periódico

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