1. Repositório Institucional da UFMG
2. Publicações Científicas e Culturais
3. Artigo de Periódico

Type:	Artigo de Periódico
Title:	Parathyroid ultrasonography and bone metabolic profile of patients on dialysis with hyperparathyroidism
Authors:	Cláudia Ribeiro Maria Goretti Moreira Guimarães Penido Milena Maria Moreira Guimarães Marcelo de Sousa Tavares Bruno Das Neves Souza Anderson Ferreira Leite Leonardo Martins Caldeira de Deus Lucas José de Campos Machado
Abstract:	To evaluate the parathyroid ultrasonography and define parameters that can predict poor response to treatment in patients with secondary hyperparathyroidism due to renal failure.METHODS:This cohort study evaluated 85 patients with chronic kidney disease stage V with parathyroid hormone levels above 800 pg/mL. All patients underwent ultrasonography of the parathyroids and the following parameters were analyzed: Demographic characteristics (etiology of chronic kidney disease, gender, age, dialysis vintage, vascular access, use of vitamin D), laboratory (calcium, phosphorus, parathyroid hormone, alkaline phosphatase, bone alkaline phosphatase), and the occurrence of bone changes, cardiovascular events and death. The χ 2 test were used to compare proportions or the Fisher exact test for small sample frequencies. Studentt-test was used to detect differences between the two groups regarding continuous variables.RESULTS: Fifty-three patients (66.4%) had parathyroid nodules with higher levels of parathyroid hormone, calcium and phosphorus. Sixteen patients underwent parathyroidectomy and had higher levels of phosphorus and calcium × phosphorus product (P = 0.03 and P = 0.006, respectively). They also had lower mortality (32% vs 68%, P = 0.01) and lower incidence of cardiovascular or cerebrovascular events (27% vs 73%,P = 0.02). Calcium× phosphorus product above 55 mg2/dL2 [RR 1.48 (1.06,2.08), P = 0.03], presence of vascular calcification [1.33(1.01, 1.76), P = 0.015] and previous occurrence of vascular events [RR 2.25 (1.27, 3.98), P < 0.001] were risk factors for mortality in this population. There was no association between the occurrence of nodules and mortality. CONCLUSION:The identification of nodules at ultrasonography strengthens the indication for parathyroidectomy in patients with secondary hyperparathyroidism due to renal failure.
Subject:	Hiperparatireoidismo Secundário Sinalização do Cálcio Fósforo Hormônio Paratireóideo Alkaline phosphatase Fosfatase Alcalina Insuficiência Renal Crônica
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE PEDIATRIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.5527/wjn.v5.i5.437
URI:	http://hdl.handle.net/1843/56912
Issue Date:	6-Sep-2016
metadata.dc.url.externa:	https://www.wjgnet.com/2220-6124/abstract/v5/i5/437.htm
metadata.dc.relation.ispartof:	World Journal of Nephrology
Appears in Collections:	Artigo de Periódico

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.