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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57182
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dc.creatorPriscila Menezes Ferri Liupt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorSoraya Luiza Campos Silvapt_BR
dc.creatorDiego Junior Queiroga de Aquinopt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.creatorDébora Marques de Mirandapt_BR
dc.creatorAlexandre Rodrigues Ferreirapt_BR
dc.date.accessioned2023-07-28T22:00:29Z-
dc.date.available2023-07-28T22:00:29Z-
dc.date.issued2016-12-16-
dc.citation.volume2016pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1155/2016/3905240pt_BR
dc.identifier.issn16876121pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57182-
dc.description.resumoPrimary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation of the biliary tree resulting in liver fibrosis. PSC is more common in male less than 40 years of age.The diagnosis of PSC is based on clinical, laboratory, image, and histological findings. A biochemical profile of mild to severe chronic cholestasis can be observed. Endoscopic retrograde cholangiography is the golden standard method for diagnosis, but magnetic resonance cholangiography is currently also considered a first-line method of investigation. Differences in clinical and laboratory findings were observed in young patients, including higher incidence of overlap syndromes, mostly with autoimmune hepatitis, higher serum levels of aminotransferases and gamma-glutamyl transferase, and lower incidence of serious complications as cholangiocarcinoma. In spite of the detection of several HLA variants as associated factors in large multicenter cohorts of adult patients, the exact role and pathways of these susceptibility genes remain to be determined in pediatric population. In addition, the literature supports a role for an altered immune response to pathogens in the pathogenesis of PSC. This phenomenon contributes to abnormal immune system activation and perpetuation of the inflammatory process. In this article, we review the role of immune and genetic factors in the pathogenesis of PSC in pediatric patients.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofGastroenterology Research and Practice-
dc.rightsAcesso Abertopt_BR
dc.subjectImmune Factorspt_BR
dc.subjectPathogenesispt_BR
dc.subjectPrimary Sclerosing Cholangitispt_BR
dc.subjectYoung Adultpt_BR
dc.subject.otherFatores imunológicospt_BR
dc.subject.otherPrimary Sclerosing Cholangitispt_BR
dc.subject.otherAdulto Jovempt_BR
dc.titleThe role of genetic and immune factors for the pathogenesis of primary sclerosing cholangitis in childhoodpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/grp/2016/3905240/pt_BR
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