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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57183
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dc.creatorAdriana Teixeirarodriguespt_BR
dc.creatorLuiz Ronaldo Albertipt_BR
dc.creatorPriscila Menezes Ferri Liupt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.creatorThaís Costa Nascentes Queirozpt_BR
dc.creatorPamela de Souza Haueisen Barbosapt_BR
dc.creatorSoraya Luiza Campos Silvapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorDébora Marques Mirandapt_BR
dc.creatorAlexandre Rodrigues Ferreirapt_BR
dc.date.accessioned2023-07-28T22:13:27Z-
dc.date.available2023-07-28T22:13:27Z-
dc.date.issued2016-07-
dc.citation.volume63pt_BR
dc.citation.issue1pt_BR
dc.citation.spage76pt_BR
dc.citation.epage81pt_BR
dc.identifier.doi10.1097/mpg.0000000000001125pt_BR
dc.identifier.issn02772116pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57183-
dc.description.resumoObjectives: This is a cohort study of 134 children and adolescents with a known diagnosis of autoimmune hepatitis (AIH). During follow-up, some of them developed autoimmune sclerosing cholangitis (ASC). This study describes the characteristics of the patients upon diagnosis, and their response to treatment and any complications, and compares the patients who developed ASC during follow-up (ASC group) with those who did not (AIH group). Methods: A total of 73.1% of the patients were girls with a median age upon diagnosis of 10.41 (7.41–12.53) years. Results: Of 134 patients, 28 (20.9%) developed cholestatic manifestations, with features of ASC. A few differences were observed between the AIH and ASC groups when they were analyzed by x2 test, such as the smaller predominance of girls in ASC group (P ¼ 0.04), and more common asymptomatic presentation in the ASC group (P ¼ 0.01). Cirrhosis was observed in 68% of biopsies, with no significant difference between groups (P ¼ 0.43). Of 16 deaths, 15 were in the AIH group and 1 in the ASC group (P ¼ 0.22). Of 11 transplants, 10 were in the AIH group and one in the ASC group (P ¼ 0.53). The presence of cirrhosis at baseline was associated with a smaller survival probability (P ¼ 0.015). The survival rate by Kaplan-Meier method was 94% at 5 years and 80% at 10 years, and was similar in both the groups (P ¼ 0.08). Conclusions: No statistically significant difference was observed between the groups in relation to prognosis and response to treatment.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition-
dc.rightsAcesso Abertopt_BR
dc.subjectAutoimmune hepatitispt_BR
dc.subjectChildrenpt_BR
dc.subjectOverlap syndromept_BR
dc.subjectPrognosticpt_BR
dc.subject.otherHepatite Autoimunept_BR
dc.subject.otherCriançapt_BR
dc.subject.otherPrognósticopt_BR
dc.titleClinical characteristics and prognosis in children and adolescents with autoimmune hepatitis and overlap syndromept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/jpgn/Fulltext/2016/07000/Clinical_Characteristics_and_Prognosis_in_Children.17.aspxpt_BR
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