1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57187
Full metadata record
DC FieldValueLanguage
dc.creatorMonique Ellen Gervásio Nunespt_BR
dc.creatorDaniela Valadão Rosapt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.creatorAlexandre Rodrigues Ferreirapt_BR
dc.creatorDébora Marques de Mirandapt_BR
dc.creatorPriscila Menezes Ferri Liupt_BR
dc.date.accessioned2023-07-28T22:46:56Z-
dc.date.available2023-07-28T22:46:56Z-
dc.date.issued2019-
dc.citation.volume56pt_BR
dc.citation.issue2pt_BR
dc.citation.spage146pt_BR
dc.citation.epage150pt_BR
dc.identifier.doihttps://doi.org/10.1590/S0004-2803.201900000-29pt_BR
dc.identifier.issn16784219pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57187-
dc.description.resumoABSTRACT – Background – Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease associated with a loss of immunological tolerance to self-antigens. Susceptibility to AIH is partially determined by the presence of genes related to human leukocyte antigen (HLA), mainly allelic variants of DRB1. Objective – The purpose of this study was to investigate the frequencies of the polymorphisms in HLA-DRB1 gene in children and adolescents with type 1 AIH and type 1 AIH overlap syndrome with autoimmune cholangitis (overlap syndrome, OS) in comparison to healthy sex and age-matched individuals (control group). Methods – This is a cross-sectional study of 25 pediatric patients diagnosed with type 1 AIH and 18 with OS. Fifty-seven healthy individuals were included as controls. The polymorphisms of the HLA-DRB1 gene were evaluated by PCR and included HLA-DRB1*03, HLA-DRB1*04, HLA-DRB1*07, and HLA-DRB1*13. Results – Our results showed that the presence of the allele HLA-DRB1*13increased the chance of autoimmune cholangitis (OR=3.96, CI 1.07 to 14.61, P=0.04). The HLA-DRB1*04 and HLA- DRB1*07 have no association with the AIH and autoimmune cholangitis in a young sample. Conclusion – This work demonstrates an association of the main polymorphisms in the HLA-DRB1 gene to AIH with or without cholangitis in a Brazilian samplept_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArquivos de Gastroenterologia-
dc.rightsAcesso Abertopt_BR
dc.subjectAutoimmune hepatitispt_BR
dc.subjectSclerosing cholangitispt_BR
dc.subjectHLA-DRB1 chainspt_BR
dc.subjectGenetic polimorphismpt_BR
dc.subject.otherHepatite Autoimunept_BR
dc.subject.otherColangite Esclerosantept_BR
dc.subject.otherCadeias HLA-DRB1pt_BR
dc.titleHla-drb1 gene polymorphisms in pediatric patients with type 1 autoimmune hepatitis and type 1 autoimmune hepatitis overlap syndrome with autoimmune cholangitispt_BR
dc.title.alternativePolimorfismos do gene HLA-DRB1 em pacientes pediátricos com hepatite autoimune tipo 1 e hepatite autoimune associada à colangite autoimune-
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/ag/a/VgYygfRYTPyQKMFP8qRPqZf/?lang=enpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
LA-DRB1 GENE POLYMORPHISMS IN PEDIATRIC PATIENTS WITH TYPE 1 AUTOIMMUNE HEPATITIS AND TYPE 1 AUTOIMMUNE HEPATITIS OVERLAP SYNDROME WITH AUTOIMMUNE CHOLANGITIS pdfa.pdf134.46 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.