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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57191
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dc.creatorJosé Ricardoborém Lopespt_BR
dc.creatorLucas Garcia de Figueiredo Colinpt_BR
dc.creatorAlexandre Rodrigues Ferreirapt_BR
dc.creatorPriscila Menezes Ferri Liupt_BR
dc.creatorThaís Costa Nascentes Queirozpt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.creatorJúlio Rocha Pimentapt_BR
dc.creatorJosé Andrade Franco Netopt_BR
dc.creatorSimone Diniz Carvalhopt_BR
dc.creatorMaria Eduarda Marques Borgespt_BR
dc.date.accessioned2023-07-28T23:43:18Z-
dc.date.available2023-07-28T23:43:18Z-
dc.date.issued2020-
dc.citation.issue72pt_BR
dc.citation.spage802pt_BR
dc.citation.epage806pt_BR
dc.identifier.doi10.1097/mpg.0000000000003039pt_BR
dc.identifier.issn02772116pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57191-
dc.description.resumoObjectives: To evaluate non-invasive predictive factors of varices with a high risk of bleeding in pediatric cirrhotic patients.Methods: This retrospective, cross-sectional study included data from 158 children with cirrhosis, median age of 5.38 years (interquartile [IQ]2.0811.52 years), and no history of upper gastrointestinal bleeding.Patients underwent an endoscopy to screen for esophageal varices. Varices with a high risk of bleeding were defined as those with a medium to large caliber, presence of red spots, or the presence of gastric varices and identified as high-risk varices (HRV). Laboratory and clinical factors were evaluated as possible predictors of HRV. Results: HRV were detected in 30 children (19%) after the first endoscopy. In the multivariate analysis, only the risk score (RS), as described by Park et al, and the aspartate aminotransferase-to-platelet ratio index (APRi) were predictive of HRV. The best non-invasive predictor of HRV was the RS with an area under the receiver operating characteristic curve of 0.764. When used a cut-off point of 1.2, the sensitivity of the RS was 90% and specificity was 53%. The use of RS or APRi correctly identified 96% of children with HRV. Conclusions: The described predictors allow the correct identification of patients with HRV. The association of RS >1.2 or APRi >1.4 has a good sensitivity to identify HRV and to prevent unnecessary endoscopy in about one-third of children with no HRV.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition-
dc.rightsAcesso Abertopt_BR
dc.subjectChildrenpt_BR
dc.subjectEsophageal varicespt_BR
dc.subjectLiver cirrhosispt_BR
dc.subject.otherCriançaspt_BR
dc.subject.otherVarizes Esofágicas e Gástricaspt_BR
dc.subject.otherCirrose Hepáticapt_BR
dc.titleNon-invasive predictors of esophageal varices with a high risk of bleeding in pediatric cirrhotic patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/jpgn/Fulltext/2021/06000/Non_invasive_Predictors_of_Esophageal_Varices_With.5.aspxpt_BR
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