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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57272
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dc.creatorZilma Silveira Nogueira Reispt_BR
dc.creatorJacqueline Braga Pereirapt_BR
dc.creatorLúcia Aparecida c. Costapt_BR
dc.creatorJuliana Silva Barrapt_BR
dc.date.accessioned2023-07-31T21:18:04Z-
dc.date.available2023-07-31T21:18:04Z-
dc.date.issued2021-
dc.citation.volume41pt_BR
dc.citation.issue5pt_BR
dc.citation.spage693pt_BR
dc.citation.epage698pt_BR
dc.identifier.doihttps://doi.org/10.1080/01443615.2020.1789851pt_BR
dc.identifier.issn01443615pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57272-
dc.description.resumoThis study aimed to evaluate soluble endoglin (sEng) in urine as a preeclampsia predictor. Ninety-three pregnant women at risk for preeclampsia were followed. Spot urine sample ELISA analysis before 20 weeks of gestation was done to assess protein levels. Logistic regression analysis evaluated associations between preeclampsia with sEng/creatinine ratio, pg/mg, adjusted for risk factors. Preeclampsia incidence was 22.8% (20/92). Urinary sEng/creatinine (pg/mg) 0.001 (95% CI 0.001–0.136) was associated, adjusted for body mass index > 28 kg/m2 OR 6.44 (95% CI 1.11–37.47) and mean arterial pressure OR 1.20 (1.07–1.35). During the first half of gestation sEng urinary excretion was lower in pregnant women developing preeclampsia.IMPACT STATEMENT: What is already known on this subject? The angiogenesis factors present in the plasma of pregnant women have shown good preclinical predictors of preeclampsia. Studies on urinary markers in pregnancy are infrequent, despite the ease of obtaining urine specimens. What do the results of this study add? Values of the sEng/creatinine ratio during the first half of pregnancy were related to a higher chance of preeclampsia occurring when it was evaluated alone or adjusted by body mass index and mean arterial pressure values. What are the implications of these findings for clinical practice and/or further research? The potential benefits of a urinary test compared to one of the blood levels include its non-invasive nature and ease of performing the test, even during prenatal care. Future research is expected to evaluate the sEng/creatinine ratio relevance to improve clinical scores of preeclampsia prediction for the identification of women at risk for this disease.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Obstetrics and Gynaecology-
dc.rightsAcesso Restritopt_BR
dc.subjectAngiogenesispt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectPregnant womanpt_BR
dc.subject.otherIndutores da Angiogênesept_BR
dc.subject.otherPré-Eclâmpsiapt_BR
dc.subject.otherGestantespt_BR
dc.titleSoluble endoglin in urine as an early-pregnancy preeclampsia marker: antenatal longitudinal feasibility studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.tandfonline.com/doi/full/10.1080/01443615.2020.1789851pt_BR
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