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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57387
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dc.creatorRodrigo Modesto Gadelha Gontijopt_BR
dc.creatorAndréa Vidal Ferreirapt_BR
dc.creatorGuilherme Cavalcante de Albuquerque Souzapt_BR
dc.creatorJuliana Batista da Silvapt_BR
dc.creatorMarcelo Mamedept_BR
dc.date.accessioned2023-08-02T21:02:48Z-
dc.date.available2023-08-02T21:02:48Z-
dc.date.issued2020-09-19-
dc.citation.volume8pt_BR
dc.citation.issue3pt_BR
dc.citation.spage01pt_BR
dc.citation.epage13pt_BR
dc.identifier.doi10.15392/bjrs.v8i3.1299pt_BR
dc.identifier.issn23190612pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57387-
dc.description.resumoPositron emission tomography (PET) is widely used in preclinical trials, generating molecular images applied to biochemical, metabolic and functional investigation of organs and tissues. The positron emitters 11C and 18F are relevant for different diseases studies. However, they have different positron energies, ranges, and branching ratio. This could result in a distinct quality between the acquired PET images. Thus, the aim of this study was to evaluate differences in the image quality performance of the PET scanner (LabPET 4, GE) at Molecular Imaging Laboratory (LIM/CDTN) depending on the use of18F or 11C. The study followed the guidelines of the NEMA NU 4-2008 standards and the recommended specific phantom was used in experimental procedures. The NEMA image-quality (IQ) phantom consists of 3 different regions to analyze distinct characteristics: uniformity, recovery coefficients (RCs) and spill-over rations (SOR) in air and water. The IQ phantom was filled with two different aqueous solutions (18F-FDG and 11C-PK11195), both activities calibrated at the beginning of acquisition (3.7MBq). The IQ phantom was placed in the center of the field-of-view (FOV) and measured with the LIM/CDTN typical whole body imaging protocol. The images were reconstructed following the LIM/CDTN standard protocol: MLEM-3D algorithm, 20 iterations, no high-resolution mode, no attenuation or scatter corrections, no post-filtering. PMOD® software was used to perform images post-processing. Uniformity test revealed that 11C PET image roughness is about twice 18F PET image roughness. SOR tests indicated around 15% more counts in cold volumesin 11C PET image than in 18F PET image. The RCs for 11C were systematically lower and with higher percentage standard deviations than those for 18F. This study demonstrated and quantified the best performance of PET images with 18F when compared to 11C. This fact must be taken into account in laboratorial practice, especially when quantitative analyzes are performed.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEMpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Radiation Sciences-
dc.rightsAcesso Abertopt_BR
dc.subjectImage Qualitypt_BR
dc.subjectPreclinical PET scannerpt_BR
dc.subject.otherTomografia por Emissão de Pósitronspt_BR
dc.subject.otherDiagnóstico por Imagempt_BR
dc.titleImage quality evaluation for two different positron emitters in a preclinical pet scannerpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.bjrs.org.br/revista/index.php/REVISTA/article/view/1299pt_BR
dc.identifier.orcid0000-0001-6479-3087pt_BR
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