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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57389
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dc.creatorIsabel V. Poggialipt_BR
dc.creatorEduardo A. Oliveirapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorMariana A. Vasconcelospt_BR
dc.creatorCristiane Dos Santos Diaspt_BR
dc.creatorIzabella R. Gomespt_BR
dc.creatorRafaela A. Carvalhopt_BR
dc.creatorMaria Christina L. Oliveirapt_BR
dc.creatorSergio V. Pinheiropt_BR
dc.creatorRobert H. Makpt_BR
dc.date.accessioned2023-08-02T22:03:06Z-
dc.date.available2023-08-02T22:03:06Z-
dc.date.issued2018-
dc.citation.volume34pt_BR
dc.citation.spage465pt_BR
dc.citation.epage474pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00467-018-4111-3pt_BR
dc.identifier.issn0931041Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57389-
dc.description.resumoBackground: Solitary functioning kidney (SFK) is an important condition in the spectrum of congenital anomalies of the kidney and urinary tract. The aim of this study was to describe the risk factors for renal injury in a cohort of patients with congenital SFK.Methods: In this retrospective cohort study, 162 patients with SFK were systematically followed up (median, 8.5 years). The primary endpoint was time until the occurrence of a composite event of renal injury, which includes proteinuria, hypertension, and chronic kidney disease (CKD). A predictive model was developed using Cox proportional hazards model and evaluated by c statistics.Results: Among 162 children with SFK included in the analysis, 132 (81.5%) presented multicystic dysplastic kidney, 20 (12.3%) renal hypodysplasia, and 10 (6.2%) unilateral renal agenesis. Of 162 patients included in the analysis, 10 (6.2%) presented persistent proteinuria, 11 (6.8%) had hypertension, 9 (5.6%) developed CKD stage ≥ 3, and 18 (11%) developed the composite outcome. After adjustment by the Cox model, three variables remained as independent predictors of the composite event:creatinine (HR, 3.93; P < 0.001), recurrent urinary tract infection (UTI) (HR, 5.05; P = 0.002), and contralateral renal length atadmission (HR, 0.974; P = 0.002). The probability of the composite event at 10 years of age was estimated as 3%, 11%, and 56% for patients assigned to the low-risk, medium-risk, and high-risk groups, respectively (P < 0.001).Conclusion: Our findings have shown an overall low risk of renal injury for most of infants with congenital SFK. Nevertheless,our prediction model enabled the identification of a subgroup of patients with an increased risk of renal injury over timept_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPediatric Nephrology-
dc.rightsAcesso Restritopt_BR
dc.subjectSolitary kidneypt_BR
dc.subjectChronic kidney diseasept_BR
dc.subjectHypertensionpt_BR
dc.subjectProteinuriapt_BR
dc.subjectUrinary tract infectionpt_BR
dc.subject.otherRim Únicopt_BR
dc.subject.otherInsuficiência Renal Crônicapt_BR
dc.subject.otherHipertensãopt_BR
dc.subject.otherProteinuriapt_BR
dc.subject.otherInfecções Urináriaspt_BR
dc.titleA clinical predictive model of renal injury in children with congenital solitary functioning kidneypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00467-018-4111-3pt_BR
dc.identifier.orcid0000-0001-6569-3300pt_BR
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