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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57562
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dc.creatorRenalice Neves Vieirapt_BR
dc.creatorLuiz Armando de Marcopt_BR
dc.creatorMarco Aurélio Romano-Silvapt_BR
dc.creatorMaria Aparecida Camargos Bicalhopt_BR
dc.creatorRafaela Ávilapt_BR
dc.creatorJonas Jardim de Paulapt_BR
dc.creatorMarco Túlio Gualberto Cintrapt_BR
dc.creatorRenan Pedra de Souzapt_BR
dc.creatorRodrigo Nicolatopt_BR
dc.creatorLeandro Malloy-Dinizpt_BR
dc.creatorDébora Marques de Mirandapt_BR
dc.creatorEdgar Nunes de Moraespt_BR
dc.date.accessioned2023-08-07T19:08:51Z-
dc.date.available2023-08-07T19:08:51Z-
dc.date.issued2016-
dc.citation.volume31pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1337pt_BR
dc.citation.epage1344pt_BR
dc.identifier.doihttps://doi.org/10.1002/gps.4440pt_BR
dc.identifier.issn0885-6230pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57562-
dc.description.resumoObjectives: In 2012, Kamboh and colleagues published a genome-wide association study that identified the DCHS2 gene (rs1466662 T/A) influencing the age at onset of Alzheimer’s disease (AD). We aimed to investigate if there is association between the DCHS2 gene and amnestic mild cognitive impairment (aMCI) and AD in a sample of the Brazilian population. Methods: 143 controls, 79 aMCI and 299 AD patients were selected and submitted to the same protocol of tests. Genotyping was performed using the Real Time PCR Results: Amnestic MCI patients showed a higher prevalence of AA than controls and a lower frequency of TT when compared with controls. We also stratified the sample according to the APOE ε4 status. No difference in DCHS2 genotype or allelic frequency occurred in the APOE ε4 allele carrier subgroup. Amnestic MCI patients showed a higher frequency of AA genotype and a lower frequency of TA and TT when compared with controls in APOE ε4 allele non-carrier subgroup. The allelic distribution followed the same pattern. In AD group, we observed a significant difference with a higher A allelic frequency in AD in this subgroup. A multiple logistic regression demonstrated that in APOE ε4 non-carriers, allele rs1466662 was associated to aMCI group. Different variables were associated with aMCI and AD according to APOE ε4 status in our sample. Low level of education was associated with AD, while diabetes mellitus type 2 was associated with aMCI. Conclusions: Our findings suggest a possible role for DCHS2 gene in aMCI and AD.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Geriatric Psychiatry-
dc.rightsAcesso Restritopt_BR
dc.subjectAlzheimer’s diseasept_BR
dc.subjectMild cognitive impairmentpt_BR
dc.subject.otherDoença de Alzheimerpt_BR
dc.subject.otherDisfunção Cognitivapt_BR
dc.titleAssociation between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian samplept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/gps.4440pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3089-655Xpt_BR
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