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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57579
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dc.creatorRaquel C. Larapt_BR
dc.creatorRodrigo P. Larapt_BR
dc.creatorC. S. Bedettipt_BR
dc.creatorE. P. Cunha-Azevedopt_BR
dc.creatorMarco Túlio Gualberto Cintrapt_BR
dc.creatorEdgar Nunes de Moraespt_BR
dc.creatorJosé Augusto Nogueira-Machadopt_BR
dc.creatorMiriam Martins Chavespt_BR
dc.date.accessioned2023-08-07T20:41:53Z-
dc.date.available2023-08-07T20:41:53Z-
dc.date.issued2018-01-23-
dc.citation.volume2pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.issn2002-7850pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57579-
dc.description.resumoThere is a large increase in the number of elderly people in modern societies. This demographic phenomenon has been paralleled by an epidemic of chronic diseases and inflammatory process usually associated with advanced age. In this work we seek to fill a gap that still exists in the process of immunoregulation “old guy’ looking to narrow the knowledge regarding their correlation with the immune system and the nervous system. The Nitric Oxide (NO) and Interleukins productions were studied in healthy subjects in age ranging from 20 to 80 years divided in three age groups: (20-39), (40-59) and (60-80) years. NO production was quantified in a Griess reaction. The results were expressed through the nitrite concentration calculated by linear regression using a standard curve obtained from a solution of sodium nitrite and 1mM RPMI. Interleukins 8, 10 and 4 (IL-8, IL-10 and IL-4) productions were measured by sandwich ELISA. Ours results demonstrated that Norepinephrine (NoAD) can no longer modulate the inflammatory cytokine profile and that there is a significant decay of the contribution of Caffeic Acid (CA) as an antioxidant and / or anti-inflammatory age-related. Thus, our results showed a lack of NoAD and CA modulation in human granulocyte in ageing dependent process.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAgeing Science & Mental Health Studies-
dc.rightsAcesso Abertopt_BR
dc.subjectAgingpt_BR
dc.subjectGranulocytept_BR
dc.subjectCaffeic acidspt_BR
dc.subjectNitric oxidpt_BR
dc.subjectCytokinespt_BR
dc.subject.otherEnvelhecimentopt_BR
dc.subject.otherGranulócitospt_BR
dc.subject.otherÁcidos Cafeicospt_BR
dc.subject.otherCitocinaspt_BR
dc.titleThe Effect of Norepinephrine and Caffeic Acid on Cytokines and Nitric Oxide Production by Granulocytes is Age-Dependentpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://researchopenworld.com/the-effect-of-norepinephrine-and-caffeic-acid-on-cytokines-and-nitric-oxide-production-by-granulocytes-is-age-dependent/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3089-655Xpt_BR
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