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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57612
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dc.creatorFelipe Antonio Girardipt_BR
dc.creatorDaniela Martí Barrospt_BR
dc.creatorGisele Eva Bruchpt_BR
dc.creatorCarolina da Silva Peixotopt_BR
dc.creatorLidiane Dal Boscopt_BR
dc.creatorSangram K. Sahoopt_BR
dc.creatorCarla Onara Ferreira Gonçalvespt_BR
dc.creatorAdelina Pinheiro Santospt_BR
dc.creatorClascídia Aparecida Furtadopt_BR
dc.creatorCristiano Fantini Leitept_BR
dc.date.accessioned2023-08-08T17:21:42Z-
dc.date.available2023-08-08T17:21:42Z-
dc.date.issued2017-
dc.citation.volume37pt_BR
dc.citation.issue2pt_BR
dc.citation.spage214pt_BR
dc.citation.epage221pt_BR
dc.identifier.doihttps://doi.org/10.1002/jat.3346pt_BR
dc.identifier.issn1099-1263pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57612-
dc.description.resumoSingle-wall carbon nanotubes functionalized with polyethylene glycol (SWCNT-PEG) are promising materials for biomedical applications such as diagnostic devices and controlled drug-release systems. However, several questions about their toxicological profile remain unanswered. Thus, the aim of this study was to investigate the action of SWCNT-PEG in Danio rerio zebrafish embryos at the molecular, physiological and morphological levels. The SWCNT used in this study were synthesized by the high-pressure carbon monoxide process, purified and then functionalized with distearoyl phosphatidylethanolamine block copolymer-PEG (molecular weight 2 kDa). The characterization process was carried out with low-resolution transmission electron microscopy, thermogravimetric analysis and Raman spectroscopy. Individual zebrafish embryos were exposed to the SWCNT-PEG. Toxic effects occurred only at the highest concentration tested (1 ppm) and included high mortality rates, delayed hatching and decreased total larval length. For all the concentrations tested, the alkaline comet assay revealed no genotoxicity, and Raman spectroscopy measurements on the histological slices revealed no intracellular nanotubes. The results shown here demonstrate that SWCNT-PEG has low toxicity in zebrafish embryos, but more studies are needed to understand what mechanisms are involved. However, the presence of residual metals is possibly among the primary mechanisms responsible for the toxic effects observed, because the purification process was not able to remove all metal contamination, as demonstrated by the thermogravimetric analysis. More attention must be given to the toxicity of these nanomaterials before they are used in biomedical applications.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Applied Toxicology-
dc.rightsAcesso Restritopt_BR
dc.subjectSingle-walled carbon nanotubespt_BR
dc.subjectEmbryotoxicitypt_BR
dc.subjectZebrafishpt_BR
dc.subject.otherNanotubos de carbonopt_BR
dc.subject.otherZebra daniopt_BR
dc.titleToxicity of single-wall carbon nanotubes functionalized with polyethylene glycol in zebrafish (Danio rerio) embryospt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.3346pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0436-7857pt_BR
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