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http://hdl.handle.net/1843/57669| Type: | Artigo de Periódico |
| Title: | Transient abnormalities in masking tuning curve in early progressive hearing loss mouse model |
| Authors: | Marion Souchal Ludimila Labanca Sirley Alves da Silva Carvalho Luciana Macedo de Resende Christelle Blavignac Paul Avan Fabrice Giraudet |
| Abstract: | Damage to cochlear outer hair cells (OHCs) usually affects frequency selectivity in proportion to hearing threshold increase. However, the current clinical heuristics that attributes poor hearing performance despite near-normal auditory sensitivity to auditory neuropathy or “hidden” synaptopathy overlooks possible underlying OHC impairment. Here, we document the part played by OHCs in influencing suprathreshold auditory performance in the presence of noise in a mouse model of progressive hair cell degeneration, the CD1 strain, at postnatal day 18–30 stages when high-frequency auditory thresholds remained near-normal. Nonetheless, total loss of high-frequency distortion product otoacoustic emissions pointed to nonfunctioning basal OHCs. This “discordant profile” came with a huge low-frequency shift of masking tuning curves that plot the level of interfering sound necessary to mask the response to a probe tone, against interfering frequency. Histology revealed intense OHC hair bundle abnormalities in the basal cochlea uncharacteristically associated with OHC survival and preserved coupling with the tectorial membrane. This pattern dismisses the superficial diagnosis of “hidden” neuropathy while underpinning a disorganization of cochlear frequency mapping with optimistic high-frequency auditory thresholds perhaps because responses to high frequencies are apically shifted. The audiometric advantage of frequency transposition is offset by enhanced masking by low-frequency sounds, a finding essential for guiding rehabilitation. |
| Subject: | Perda Auditiva Condutiva-Neurossensorial Mista Células Ciliadas Auditivas Externas |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE FONOAUDIOLOGIA MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1155/2018/6280969 |
| URI: | http://hdl.handle.net/1843/57669 |
| Issue Date: | 13-Feb-2018 |
| metadata.dc.url.externa: | https://www.hindawi.com/journals/bmri/2018/6280969/ |
| metadata.dc.relation.ispartof: | BioMed Research International |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model pdfa.pdf | 15.41 MB | Adobe PDF | View/Open |
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