Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/57713| Type: | Artigo de Periódico |
| Title: | EDTA-dependent pseudothrombocytopenia in patients with hepatosplenic schistosomiasis mansoni: a clinical management alert |
| Authors: | Guilherme Vaz de Melo Trindade Júlia Fonseca de Morais Caporali Debora Vaz de Melo Trindade Silvana Junia Roriz Thiago Almeida Pereira Patrícia Donado Vaz de Melo José Roberto Lambertucci |
| Abstract: | platelet counts are required for identification and management of HS patients. EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of anticoagulant-activated platelet agglutination resulting in low platelet counts by automated methods. The prevalence of EDTA-PCTP in schistosomiasis is unknown and only one case has been described. Our aims were to determine the prevalence of EDTA-PTCP in HS and evaluate alternative methods to overcome this analytical error. Methods: Blood samples from 56 HS patients and 56 healthy volunteers were collected, and platelet counts were obtained using standard microscopy and automated (electric impedance) methods. Automated platelet counts and the presence of platelet clumps in blood smears were evaluated in samples collected in EDTA or sodium citrate tubes 20 and 180 min after blood collection. Results: EDTA-PTCP was more frequent in HS patients than healthy volunteers (8.92% vs 0.00%, p<0.0285). Platelet clumps and PTCP were also observed in samples collected in sodium citrate tubes, refuting its use as an alternative method. Conclusions: Automated platelet counts in blood samples from HS patients should be performed right after blood collection in EDTA tubes and verified by manual counts in blood smears. |
| Subject: | Esquistossomose mansoni Contagem de Plaquetas Citrato de Sódio |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1093/trstmh/trab034 |
| URI: | http://hdl.handle.net/1843/57713 |
| Issue Date: | 15-Feb-2021 |
| metadata.dc.url.externa: | https://academic.oup.com/trstmh/article/115/10/1168/6159779?login=true |
| metadata.dc.relation.ispartof: | Transactions of The Royal Society of Tropical Medicine and Hygiene |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.