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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57772
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dc.creatorTomás Reinertpt_BR
dc.creatorAngélica Nogueira Rodriguespt_BR
dc.creatorFabiola Procacci Kestelmanpt_BR
dc.creatorPatricia Ashton-Prollapt_BR
dc.creatorMárcia Silveira Graudenzpt_BR
dc.creatorJosé Binespt_BR
dc.date.accessioned2023-08-11T21:01:08Z-
dc.date.available2023-08-11T21:01:08Z-
dc.date.issued2018-03-12-
dc.citation.volume18pt_BR
dc.citation.issue4pt_BR
dc.citation.spagee-87pt_BR
dc.citation.epagee-94pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.clbc.2018.03.006pt_BR
dc.identifier.issn1526-8209pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57772-
dc.description.resumoThis narrative literature review addresses the problem of an adnexal mass discovered during the course of breast cancer (BC) care, which may represent a benign condition, a metastatic process, or a primary ovarian cancer (OC),clinical scenarios associated with distinct physiopathology and prognosis. Furthermore, the coexistence of BC and OC in the same patient may be owing to a hereditary disorder, deserving specific management strategies and counseling. The initial detection and evaluation of an adnexal mass in a patient with BC requires a high index of suspicion, and the initial workup should include a thorough medical history and physical examination, measurement of tumor markers, complete blood count, and imaging tests. Transvaginal ultrasonography remains the standard tool, and findings suggestive of malignancy include bilateral tumors, thick septations, predominance of a solid component,Doppler flow to the solid component, and ascites. From the pathology point of view, features that are suggestive of metastatic disease include bilaterality, mild ovarian enlargement, vascular emboli, no omental deposits, and the absence of transition from benign to malignant epithelium. Although there is a considerable overlap in OC and BC immunohistochemical profiles, BC usually stain positive for GCDFP-15 and negative for vimentine, PAX8, and WT1, and OC often stain positive for CK7, PAX8, WT1, and to mesothelin. Genetic counselling should always be indicated in this clinical scenario. In conclusion, diagnostic spectrum of an ovarian mass in a patient with BC is broad, and a systematic multi-professional strategy is necessary to conduct these challenging cases.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Breast Cancer-
dc.rightsAcesso Restritopt_BR
dc.subjectBRCA mutationpt_BR
dc.subjectBreast neoplasmspt_BR
dc.subjectOvarian Neoplasmspt_BR
dc.subjectBiomarkers, Tumorpt_BR
dc.subject.otherNeoplasias Ovarianaspt_BR
dc.subject.otherNeoplasias da Mamapt_BR
dc.subject.otherMarcadores tumoraispt_BR
dc.titleThe challenge of evaluating adnexal masses in breast cancer patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1526820918300260?via%3Dihubpt_BR
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