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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57816
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dc.creatorLuiz Claudio Santos Thulerpt_BR
dc.creatorBárbara Reis Warisspt_BR
dc.creatorAngélica Nogueira Rodriguespt_BR
dc.creatorAndreia Cristina de Melopt_BR
dc.creatorAnke Bergmannpt_BR
dc.date.accessioned2023-08-14T21:09:12Z-
dc.date.available2023-08-14T21:09:12Z-
dc.date.issued2021-07-21-
dc.citation.volume264pt_BR
dc.citation.spage281pt_BR
dc.citation.epage288pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejogrb.2021.07.034pt_BR
dc.identifier.issn0301-2115pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57816-
dc.description.resumoObjective: Inflammation plays a crucial role in the initiation and progression of many cancers. This study aimed to investigate the utility of pretreatmentneutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), derived neutrophil–lymphocyte ratio (dNLR), and a combination of PLR and NLR in predicting the risk of death according to clinical staging in cervical cancer (CC) patients.Methods: A cohort study of women with CC, diagnosed and treated at a single cancer referral center in Brazil, from 2006 to 2009. A multivariate Cox regression analysis and ROC curve analysis accessed the predictive value of inflammatory response biomarkers in overall survival (OS). The median values of the biomarkers were used as cut-off points.Results: A total of 1,266 patients were included in the study, 76.0% with locally advanced disease. After adjusting for clinical variables, NLR > 2.57, PLR 146.70, dNLR 1.778 and PLR + NLR in combination had equivalent performance in predicting worse OS, but only among patients with locally advanced disease (adjusted Hazard Ratio [aHR] = 1.453, 95% Confidence Interval [CI] = 1.227–1.722; p < 0.001; aHR = 1.429; 95% CI = 1.209–1.688; p < 0.001; aHR = 1.486, 95% CI = 1.257–1.756, p < 0.001, aHR = 1.731; 95% CI = 1.411–2.123; p < 0.001, respectively).Conclusion: In conclusion, PLR, NLR, dNLR and PLR + NLR in combination presented equivalent perfor mance in predicting OS in locally advanced CC patients. They are simple and readily available from rou tine blood tests, not entailing additional costs. PLR, NLR, dNLR and PLR + NLR in combination are strong prognostic biomarkers candidates in locally advanced CC and should be further explored in prospective trials.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology-
dc.rightsAcesso Restritopt_BR
dc.subjectInflammatory markerspt_BR
dc.subjectCervical Cancerpt_BR
dc.subjectSurvivalpt_BR
dc.subjectClinical stagingpt_BR
dc.subject.otherNeoplasias do Colo do Úteropt_BR
dc.subject.otherSobrevivênciapt_BR
dc.titleThe utility of pretreatment systemic inflammatory response biomarkers on overall survival of cervical cancer patients stratified by clinical stagingpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ejog.org/article/S0301-2115(21)00377-8/fulltextpt_BR
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