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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/57868
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dc.creatorVivianne Carvalho da Cunha Trajanopt_BR
dc.creatorCláudia Borges Brasileiropt_BR
dc.creatorJonathas Antônio de Souza Henriquespt_BR
dc.creatorLuís de Miranda Cotapt_BR
dc.creatorCélia Regina Lanzapt_BR
dc.creatorMaria Esperanza Cortéspt_BR
dc.date.accessioned2023-08-16T22:25:29Z-
dc.date.available2023-08-16T22:25:29Z-
dc.date.issued2020-01-10-
dc.citation.volume33pt_BR
dc.citation.issuespt_BR
dc.citation.spagee112pt_BR
dc.citation.epagespt_BR
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2019.vol33.0112pt_BR
dc.identifier.issn18073107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/57868-
dc.description.resumoThis clinical trial compared the efficacy of doxycycline (DOX) in β-cyclodextrin (DOX)/βCD) with DOX- alone in gel on thirty-three subjects with periodontitis. Patients were randomized to group 1 GI; 10% DOX + scaling and root planning (SRP); group 2 (GII (10% DOX /β-CD + SRP), and group 3 (GIII; SRP). Gels were applied in GI and GII at baseline (T0) and 30 days later (T1). Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and Visible Plaque Index (VPI) were evaluated at (T0), 30 days (T1) and 60 days after T0 (T2). Bone density was analyzed after 18 months (T3). GII showed the most significant reduction of PPD (2.62 mm; p <0.003), and greatest gain in CAL (2.54 mm p <0.003) at T2. BOP and the VPI had a strong reduction in all groups at T2 (p <0.05), both decreased by ≥5 times and 2 times, respectively, in all groups at T1. Bone density increased in all groups in radiographs (T3). The use of DOX encapsulated in β-CD gel with SRP resulted in significant improvements in clinical periodontal parameters; such molecular inclusion of doxycycline into β-CD in gel for local application is relatively simple and useful in dentistrypt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectb-cyclodextrinpt_BR
dc.subjectbiomateriais, cultura celularpt_BR
dc.subjectdoxycyclinept_BR
dc.subjectGÉIS BIODEGRADÁVEISpt_BR
dc.subjectENSAIO CLÍNICOpt_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherDoxycyclinept_BR
dc.subject.otherGelspt_BR
dc.subject.other2-Hydroxypropyl-beta-cyclodextrinpt_BR
dc.subject.otherBone densitypt_BR
dc.subject.otherDental plaquept_BR
dc.subject.otherPeriodontal indexpt_BR
dc.titleDoxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trialpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/5ybFmr5jzSSgGHgC3bdKMrG/?lang=en#pt_BR
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