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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/58094
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dc.creatorCinthia Verónica Bardalez Lopezpt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorCeleste Sánchez-romeropt_BR
dc.creatorBelinda Bunnpt_BR
dc.creatorWillie Van Heerdenpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.date.accessioned2023-08-22T20:27:06Z-
dc.date.available2023-08-22T20:27:06Z-
dc.date.issued2020-
dc.citation.volume30pt_BR
dc.citation.issue6pt_BR
dc.citation.spage617pt_BR
dc.citation.epage625pt_BR
dc.identifier.doihttps://doi.org/10.1590/0103-6440201902599pt_BR
dc.identifier.issn0103-6440pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/58094-
dc.description.abstractO objetivo deste estudo foi determinar se a distribuição das células de Langerhans (CL) e das células dendríticas intersticiais (CDI) está alterada no sarcoma de Kaposi oral associado à AIDS quando comparado às lesões orais altamente vasculares HIV-negativas. 51 casos de sarcoma de Kaposi oral associado à AIDS e 20 de lesões orais altamente vasculares foram recuperados retrospectivamente. Todos os casos de sarcoma de Kaposi foram confirmados pela positividade para os anticorpos CD34 e HHV-8. Dados clínicos sobre sexo, idade e localização das lesões foram obtidos dos laudos histopatológicos. Foram realizadas imunoistoquímica contra CD207 (células dendríticas imaturas) e CD83 (células dendríticas maduras). As CL estavam presentes no epitélio enquanto as CDI estavam presentes no estroma. As células CD207+ predominaram no epitélio das lesões, enquanto as células CD83+ predominaram no estroma. O sarcoma de Kaposi teve uma contagem mais baixa de CD imaturas CD207+ (p = 0,02) e número aumentado de CDC CD207+ do que lesões orais altamente vasculares (p<0,001). Além disso, o sarcoma de Kaposi também mostrou um número aumentado de CDI CD83+ maduras do que lesões orais altamente vasculares (p<0,001). Houve alterações significativas na distribuição de CL e CDI no sarcoma de Kaposi associado à AIDS quando comparado às lesões orais vasculares HIV-negativas, sugerindo que alterações na distribuição das mesmas podem desempenhar um papel na patogênese do sarcoma de Kaposi.pt_BR
dc.description.resumoThe role of digital pathology in remote reporting has seen an increase during the COVID-19 pandemic. Recently, recommendationshadbeenmaderegardingtheurgentneedofreorganizingheadandneckcancerdiagnosticservicestoprovideasafework environment for the staff. A total of 162 glass slides from 109 patients over a period of 5 weeks were included in this validation and were assessed by all pathologists in both analyses (digital and conventional) to allow intraobserver comparison. The intraobserver agreement between the digital method (DM) and conventional method (CM) was considered almost perfect (κ rangedfrom0.85to0.98,with95%CI,rangingfrom0.81to1).Themostsignificantandfrequentdisagreementswithintrainees encompassed epithelialdysplasia grading and differentiation among severe dysplasia (carcinoma insitu) and oral squamous cell carcinoma.ThemostfrequentpitfallfromDMwaslaginscreenmirroring.Thelackofdetailsofinflammatorycellsandtheneed for a higher magnification to assess dysplasia were pointed in one case each. The COVID-19 crisis has accelerated and consolidated the use of online meeting tools, which would be a valuable resource even in the post-pandemic scenario. Adaptation in laboratory workflow, the advent of digital pathology and remote reporting can mitigate the impact of similar future disruptions to the oral and maxillofacial pathology laboratory workflow avoiding delays in diagnosis and report, to facilitate timely management of head and neck cancer patients.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Dental Journalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectRemote reportingpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectDigital microscopypt_BR
dc.subjectOral and maxillofacial pathologypt_BR
dc.subjectDigital pathologypt_BR
dc.subjectLaboratory workflowpt_BR
dc.subject.otherCOVID-19pt_BR
dc.titleDistribution of Dendritic Cells in AIDS-Associated Oral Kaposi’s Sarcomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bdj/a/cb5VDk3LXRPqjmXH3HcqBqC/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9032-2067pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1840-4911pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5365-2692pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5699-4997pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2494-667Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6657-4547pt_BR
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