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http://hdl.handle.net/1843/58677| Type: | Artigo de Periódico |
| Title: | Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression |
| Authors: | Pedro A. C. Costa Mauro C. X. Pinto Jaime H. Amorim Vasco Ariston de Carvalho Azevedo Rodrigo R. Resende Remo C. Russo Thiago M. Cunha Pedro A. F. Galante Akiva Mintz Alexander Birbrair Walison N. Silva Pedro H. D. M. Prazeres Caroline C. Picoli Gabriela D. A. Guardia Alinne C. Costa Mariana A. Oliveira Pedro P. G. Guimarães Ricardo Gonçalves |
| Abstract: | Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor progression remains unknown. Here we used Designer Receptors Exclusively Activated by a Designer Drug (DREADD) technology to inhibit or activate sensory neurons’ firing within the melanoma tumor. Melanoma growth and angiogenesis were accelerated following inhibition of sensory neurons’ activity and were reduced following overstimulation of these neurons. Sensory neuron-specific overactivation also induced a boost in the immune surveillance by increasing tumor-infiltrating anti-tumor lymphocytes, while reducing immune-suppressor cells. In humans, a retrospective in silico analysis of melanoma biopsies revealed that increased expression of sensory neurons-related genes within melanoma was associated with improved survival. These findings suggest that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes. |
| Subject: | Células Receptoras Sensoriais Microambiente Tumoral Melanoma |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1186/s40478-021-01273-9 |
| URI: | http://hdl.handle.net/1843/58677 |
| Issue Date: | 16-Nov-2021 |
| metadata.dc.url.externa: | https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01273-9#rightslink |
| metadata.dc.relation.ispartof: | Acta Neuropathologica Communications |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression.pdf | 1.96 MB | Adobe PDF | View/Open |
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