1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/58729
Full metadata record
DC FieldValueLanguage
dc.creatorVivian Petersen Wagnerpt_BR
dc.creatorLiana Preto Weberpt_BR
dc.creatorGabriela Salvadoript_BR
dc.creatorLuize Meurerpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorRogério Moraes Castilhopt_BR
dc.creatorCristiane Helena Squarizept_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.date.accessioned2023-09-15T18:35:03Z-
dc.date.available2023-09-15T18:35:03Z-
dc.date.issued2016-
dc.citation.volume95pt_BR
dc.citation.issue22pt_BR
dc.citation.spagee3725pt_BR
dc.identifier.doihttps://doi.org/10.1097%2FMD.0000000000003725pt_BR
dc.identifier.issn00257974pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/58729-
dc.description.resumoThe DNA mismatch repair (MMR) system is responsible for the detection and correction of errors created during DNA replication, thereby avoiding the incorporation of mutations in dividing cells. The prognostic value of alterations in MMR system has not previously been analyzed in oral squamous cell carcinoma (OSCC).The study comprised 115 cases of OSCC diagnosed between 1996 and 2010. The specimens collected were constructed into tissue microarray blocks. Immunohistochemical staining for MutSα complex proteins hMSH2 and hMSH6 was performed. The slides were subsequently scanned into high-resolution images, and nuclear staining of hMSH2 and hMSH6 was analyzed using the Nuclear V9 algorithm. Univariable and multivariable Cox proportional hazard regression models were performed to evaluate the prognostic value of hMSH2 and hMSH6 in OSCC.All cases in the present cohort were positive for hMSH2 and hMSH6 and a direct correlation was found between the expression of the proteins (P < 0.05). The mean number of positive cells for hMSH2 and hMSH6 was 64.44 ± 15.21 and 31.46 ± 22.38, respectively. These values were used as cutoff points to determine high protein expression. Cases with high expression of both proteins simultaneously were classified as having high MutSα complex expression. In the multivariable analysis, high expression of the MutSα complex was an independent prognostic factor for poor overall survival (hazard ratio: 2.75, P = 0.02).This study provides a first insight of the prognostic value of alterations in MMR system in OSCC. We found that MutSα complex may constitute a molecular marker for the poor prognosis of OSCC.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMedicinept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectfao clínica assunto carcinoma, proteina. busca dia 28 do 08 agosto ano 2023,pt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherLaminspt_BR
dc.subject.otherDNApt_BR
dc.subject.otherDNA repairpt_BR
dc.titleOverexpression of mutSα complex proteins predicts poor prognosis in oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/md-journal/fulltext/2016/05310/overexpression_of_muts__complex_proteins_predicts.13.aspxpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Overexpression of mutSα complex proteins predicts poor prognosis in oral squamous cell carcinoma.pdf962.06 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.