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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/58812
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dc.creatorGleyson Kleber do Amaral Silvapt_BR
dc.creatorAlan Roger dos Santos-Silvapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorCeleste Sánchez-Romeropt_BR
dc.creatorVivian Petersen Wagnerpt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorEduardo Rodrigues Fregnanipt_BR
dc.creatorFernando Augusto Soarespt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorAndré Caroli Rochapt_BR
dc.date.accessioned2023-09-20T19:12:00Z-
dc.date.available2023-09-20T19:12:00Z-
dc.date.issued2017-09-
dc.citation.volume124pt_BR
dc.citation.issue3pt_BR
dc.citation.spage286pt_BR
dc.citation.epage295pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2017.05.511pt_BR
dc.identifier.issn22124403pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/58812-
dc.description.resumoObjective: The aim of this study was to investigate hMutS proteins in developing human tooth, ameloblastomas, and ameloblastic carcinoma and to determine whether the expression of these proteins has any prognostic potential. Study design: Ten cases of developing human tooth, 39 ameloblastomas, and 2 ameloblastic carcinomas were used to determine the distribution of the proteins during the process of carcinogenesis. Simultaneously, another sample of 73 ameloblastomas was arranged in tissue microarray, and their clinical, microscopic, and radiographic features; treatment outcome; presence of BRAF-V600E mutation; and follow-up data were assessed to determine the prognostic relevance of the expression of hMutS (hMSH2, hMSH3, hMSH6) and Ki-67. hMSH2 and hMSH6 were significantly downexpressed in ameloblastomas (P = .0059) compared with developing human tooth (P < .0001). Results: hMSH2, hMSH3 expression were significantly associated with BRAF-V600E mutation (P < .05). Simultaneous overexpression of hMutS was associated with recurrence (P = .035); however, these did not predict the disease-free survival of patients (P > .05). Conclusions: hMutS proteins are downregulated in ameloblastoma; moreover, simultaneous overexpression of these proteins in ameloblastoma was associated with recurrence but did not predict disease-free survival.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherToothpt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherAmeloblastomapt_BR
dc.subject.otherMutationpt_BR
dc.subject.otherRecurrencept_BR
dc.titlePrognostic significance of hmsh2, hmsh3, and hmsh6 expression in ameloblastomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440317308313?via%3Dihubpt_BR
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