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http://hdl.handle.net/1843/58869| Type: | Artigo de Periódico |
| Title: | Reduced chromatin acetylation of malignant salivary gland tumors correlates with enhanced proliferation. |
| Authors: | Vivian Petersen Wagner Manoela Domingues Martins Douglas Magno Guimarães Artur Cunha Vasconcelos Luize Meurer Pablo Augustin Vargas Felipe Paiva Fonseca Cristiane Helena Squarize Rogério Moraes Castilho |
| Abstract: | Background: Epigenetic changes refer to any heritable modification in gene expression independent of alterations in the DNA sequence. Currently, it is well established that epigenetics represents a crucial player for tumor development. Nevertheless, the epigenetic mechanisms involved in the development and progression of salivary gland tumors (SGTs) remain poorly understood. Methods: In this study, we analyzed the pattern of acetyl-histone H3 (lys9) expression in benign and malignant SGTs and further correlate our results with tumors' proliferative activity and clinical outcomes. We assembled tissue microarrays (TMAs) of 84 cases of SGTs and analyzed for acetyl-histone H3 (lys9) and Ki-67 using immunohistochemistry. The study comprised 42 benign and 42 malignant SGTs. Results: All cases included in this study were positive to acetyl-H3 (lys9). We observed that malignant SGTs were hypoacetylated compared with benign (P = 0.04). Moreover, acetyl-H3 (lys9) expression was inversely correlated with Ki67 (**P = 0.02). Conclusion: This study provides the first insight regarding histone modifications in SGTs. Our results suggest that epigenetic mechanism, particularly hypoacetylation of histone H3 (lys9), might play a role in the behavior of salivary gland tumors. Also, our findings suggest that interfering with the acetylation pattern of tumor histones represents a potential novel therapeutic strategy for the treatment of SGTs |
| Subject: | Acetylation Epigenomics Neoplasms Histones Immunohistochemistry Salivary gland neoplasms |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jop.12557 |
| URI: | http://hdl.handle.net/1843/58869 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.12557 |
| metadata.dc.relation.ispartof: | Journal oral pathology & Medicine |
| Appears in Collections: | Artigo de Periódico |
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