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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59077
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dc.creatorChams Bmalufpt_BR
dc.creatorFrancesco p Cappucciopt_BR
dc.creatorMichelle a Millerpt_BR
dc.creatorSandhi Maria Barretopt_BR
dc.creatorLuana Giattipt_BR
dc.creatorAntonio Luiz Pinho Ribeiropt_BR
dc.creatorPedro g Vidigalpt_BR
dc.creatorDouglas r m Azevedopt_BR
dc.creatorRosane h Grieppt_BR
dc.creatorSheila Maria Alvim Matospt_BR
dc.creatorChen jipt_BR
dc.date.accessioned2023-10-02T21:38:43Z-
dc.date.available2023-10-02T21:38:43Z-
dc.date.issued2020-01-22-
dc.citation.volume74pt_BR
dc.citation.spage421pt_BR
dc.citation.epage427pt_BR
dc.identifier.doidoi:10.1136/jech-2019-213289pt_BR
dc.identifier.issn0143005Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59077-
dc.description.resumoBackground High-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population. Methods Baseline data (2008–2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.Results The risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had selfreported medical history of diabetes, cancer and chronic obstructive pulmonary disease.Conclusions Our study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Epidemiology and Community Health-
dc.rightsAcesso Abertopt_BR
dc.subjectC reactive proteinpt_BR
dc.subjectMortalitypt_BR
dc.subjectCardiovascular Diseasespt_BR
dc.subject.otherC-Reactive Proteinpt_BR
dc.subject.otherMortalitypt_BR
dc.subject.otherCardiovascular Diseasespt_BR
dc.titleAssociation between c reactive protein and all-cause mortality in the elsa-brasil cohortpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://pubmed.ncbi.nlm.nih.gov/32102838/pt_BR
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