Use este identificador para citar ou linkar para este item:
http://hdl.handle.net/1843/59077| Tipo: | Artigo de Periódico |
| Título: | Association between c reactive protein and all-cause mortality in the elsa-brasil cohort |
| Autor(es): | Chams Bmaluf Francesco p Cappuccio Michelle a Miller Sandhi Maria Barreto Luana Giatti Antonio Luiz Pinho Ribeiro Pedro g Vidigal Douglas r m Azevedo Rosane h Griep Sheila Maria Alvim Matos Chen ji |
| Resumo: | Background High-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population. Methods Baseline data (2008–2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.Results The risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had selfreported medical history of diabetes, cancer and chronic obstructive pulmonary disease.Conclusions Our study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables. |
| Assunto: | C-Reactive Protein Mortality Cardiovascular Diseases |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | doi:10.1136/jech-2019-213289 |
| URI: | http://hdl.handle.net/1843/59077 |
| Data do documento: | 22-Jan-2020 |
| metadata.dc.url.externa: | https://pubmed.ncbi.nlm.nih.gov/32102838/ |
| metadata.dc.relation.ispartof: | Journal of Epidemiology and Community Health |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Association between C reactive protein and all-cause pdfa.pdf | 597.95 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.