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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59195
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dc.creatorCarla Isabelly Rodrigues-Fernandespt_BR
dc.creatorLucas Lacerda de Souzapt_BR
dc.creatorSara Ferreira dos Santos Costapt_BR
dc.creatorAndré Myller Barbosa Silvapt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorPeter Brennanpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.date.accessioned2023-10-05T19:17:06Z-
dc.date.available2023-10-05T19:17:06Z-
dc.date.issued2018-
dc.citation.volume47pt_BR
dc.citation.spage915pt_BR
dc.citation.epage922pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12753pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59195-
dc.description.resumoBackground: Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. Purpose: To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors. Methods: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018. Inclusion criteria comprised cases diagnosed as PBL affecting the oral cavity and gnathic bones with sufficient data to confirm the diagnoses. Results: A total of 70 publications were included, representing 153 cases. Oral PBL predominantly affected HIV-positive males (76.4%). EBV was observed in 63.4% of the cases. The gingiva was the most involved site and the lesion usually presented as an asymptomatic swelling. Most cases were classified as stage I (21.6%), and chemotherapy alone was applied in 28.8% of the cases. There was a significant association between HIV and EBV infections, and cases affecting HIV-negative patients were more common in older individuals. Cumulative survival of the patients achieved 42.4% and 33.5% after 2 and 5 years, respectively. Although there were no statistically significant clinicopathological parameters in the univariate analysis, the multivariate Cox regression model demonstrated that EBV-positive status, presence of B-symptoms, and chemotherapy alone were independent prognostic determinants of a poor prognosis. Conclusion: Oral PBL is an aggressive neoplasm with low survival rates, which is influenced by the presence of EBV, presence of B-symptoms, and with the use of chemotherapy only.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectbusca 09 do 09 2023 fao clínica assunto HIV acesso restritopt_BR
dc.subject.otherEpstein-Barr virus infectionspt_BR
dc.subject.otherHIVpt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherPlasmablastic Lymphomapt_BR
dc.subject.otherDrug therapypt_BR
dc.titleClinicopathological analysis of oral plasmablastic lymphoma: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12753pt_BR
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