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http://hdl.handle.net/1843/59195| Tipo: | Artigo de Periódico |
| Título: | Clinicopathological analysis of oral plasmablastic lymphoma: a systematic review |
| Autor(es): | Carla Isabelly Rodrigues-Fernandes Lucas Lacerda de Souza Sara Ferreira dos Santos Costa André Myller Barbosa Silva Hélder Antônio Rebelo Pontes Márcio Ajudarte Lopes Oslei Paes de Almeida Peter Brennan Felipe Paiva Fonseca |
| Resumo: | Background: Plasmablastic lymphoma (PBL) is a high-grade lymphoma that often affects the oral cavity of HIV-positive patients; however, its prognostic determinants remain unknown. Purpose: To integrate the available data on oral PBL to determine its clinicopathological features and to identify potential prognostic factors. Methods: An electronic systematic review was performed using multiple databases with a specific search strategy in February 2018. Inclusion criteria comprised cases diagnosed as PBL affecting the oral cavity and gnathic bones with sufficient data to confirm the diagnoses. Results: A total of 70 publications were included, representing 153 cases. Oral PBL predominantly affected HIV-positive males (76.4%). EBV was observed in 63.4% of the cases. The gingiva was the most involved site and the lesion usually presented as an asymptomatic swelling. Most cases were classified as stage I (21.6%), and chemotherapy alone was applied in 28.8% of the cases. There was a significant association between HIV and EBV infections, and cases affecting HIV-negative patients were more common in older individuals. Cumulative survival of the patients achieved 42.4% and 33.5% after 2 and 5 years, respectively. Although there were no statistically significant clinicopathological parameters in the univariate analysis, the multivariate Cox regression model demonstrated that EBV-positive status, presence of B-symptoms, and chemotherapy alone were independent prognostic determinants of a poor prognosis. Conclusion: Oral PBL is an aggressive neoplasm with low survival rates, which is influenced by the presence of EBV, presence of B-symptoms, and with the use of chemotherapy only. |
| Assunto: | Epstein-Barr virus infections HIV Mouth Plasmablastic Lymphoma Drug therapy |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1111/jop.12753 |
| URI: | http://hdl.handle.net/1843/59195 |
| Data do documento: | 2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.12753 |
| metadata.dc.relation.ispartof: | Journal of Oral Pathology & Medicine |
| Aparece nas coleções: | Artigo de Periódico |
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