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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59207
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dc.creatorEnrrico Bloisept_BR
dc.creatorPasquapina Ciarmelapt_BR
dc.creatorCynthia Dela Cruzpt_BR
dc.creatorStefano Luisipt_BR
dc.creatorFelice Petragliapt_BR
dc.creatorFernando Marcos Dos Reispt_BR
dc.date.accessioned2023-10-05T22:27:41Z-
dc.date.available2023-10-05T22:27:41Z-
dc.date.issued2019-
dc.citation.volume99pt_BR
dc.citation.issue1pt_BR
dc.citation.spage739pt_BR
dc.citation.epage780pt_BR
dc.identifier.doihttps://doi.org/10.1152/physrev.00002.2018pt_BR
dc.identifier.issn0031-9333pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59207-
dc.description.resumoActivins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. The current understanding of activin A surpasses the reproductive system and allows its classification as a hormone, a growth factor, and a cytokine. In more than 30 yr of intense research, activin A was localized in female and male reproductive organs but also in other organs and systems as diverse as the brain, liver, lung, bone, and gut. Moreover, its roles include embryonic differentiation, trophoblast invasion of the uterine wall in early pregnancy, and fetal/neonate brain protection in hypoxic conditions. It is now recognized that activin A overexpression may be either cytostatic or mitogenic, depending on the cell type, with important implications for tumor biology. Activin A also regulates bone formation and regeneration, enhances joint inflammation in rheumatoid arthritis, and triggers pathogenic mechanisms in the respiratory system. In this 30-yr review, we analyze the evidence for physiological roles of activin A and the potential use of activin agonists and antagonists as therapeutic agents.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPhysiological Reviewspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectActivinpt_BR
dc.subjectMammalian Physiologypt_BR
dc.subject.otherMamiferospt_BR
dc.titleActivin a in mammalian physiologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.physiology.org/doi/full/10.1152/physrev.00002.2018#:~:text=Activin%20A%20is%20a%20critical,during%20embryonic%20development%20(279).pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0275-8686pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4400-3786pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1236-9142pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3602-0666pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8851-625Xpt_BR
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