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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59321
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dc.creatorCarmindo R. Borelpt_BR
dc.creatorLuiz Cláudio de Almeida Barbosapt_BR
dc.creatorCélia Malthapt_BR
dc.creatorSergio Fernandespt_BR
dc.creatorLarissa Santospt_BR
dc.creatorJacqueline Takahashipt_BR
dc.date.accessioned2023-10-09T23:01:55Z-
dc.date.available2023-10-09T23:01:55Z-
dc.date.issued2017-
dc.citation.volume40pt_BR
dc.citation.issue9pt_BR
dc.citation.spage1065pt_BR
dc.citation.epage1073pt_BR
dc.identifier.doihttps://doi.org/10.21577/0100-4042.20170118pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59321-
dc.description.resumoIn this work a series of 2-(2- pyridyl)quinolines were prepared via a Povarov reaction between anilines, 2-pyridinocarbadehyde and ethyl vinyl ether under microwaves heating conditions. The optimized conditions herein reported allowed the preparation of several pyridylquinolines in yields in the range of 30-83%, some of them not previously accessible by this multicomponent process. The reported methodology has advantage over previous report due to its larger scope and short reaction time (2 hours). All quinolines obtained were assayed against five species of clinically important yeasts Candida sp and against Cryptococcus neoformans. Some of them possessed a broad spectrum of action including 2-(2-pyridyl)quinoline (20) and 6,8-dimethoxy-2-(pyridin-2-yl)quinolone (22) that were highly effective in inhibiting Candida species (IC50 < 1.95 µg/mL against C. tropicalis and C. krusei). Some compounds were more potent than commercial drugs Nistatin and Miconazole.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofQuímica Novapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPyridylquinolinept_BR
dc.subjectAntifungalpt_BR
dc.subjectPovarov reactionpt_BR
dc.subjectCycloadditionpt_BR
dc.subjectCandida spppt_BR
dc.subject.otherMicroondaspt_BR
dc.subject.otherAtividade antifúngicaspt_BR
dc.titleSíntese de 2-(2-piridil)quinolinas promovida por micro-ondas e suas atividades antifúngicaspt_BR
dc.title.alternativeSynthesis of 2-(2-pyridyl)quinolines promoted mby microwaves and their antigungal activitiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/qn/a/jc7LwYFcTfXr3ztJ5YjZhpv/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5395-9608pt_BR
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