1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59325
Full metadata record
DC FieldValueLanguage
dc.creatorMariane Beatriz Sordipt_BR
dc.creatorThais Altoe Moreirapt_BR
dc.creatorJuan Felipe Dumespt_BR
dc.creatorLuiz Cláudio de Almeida Barbosapt_BR
dc.creatorCesar Augusto Magalhaes Benfattipt_BR
dc.creatorAndrea de Lima Pimentapt_BR
dc.creatorJulio Cesar Matia de Souzapt_BR
dc.date.accessioned2023-10-09T23:05:49Z-
dc.date.available2023-10-09T23:05:49Z-
dc.date.issued2018-
dc.citation.volume26pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2017-0065pt_BR
dc.identifier.issn1678-7765pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59325-
dc.description.resumoConsidering oral diseases, antibiofilm compounds can decrease the accumulation of pathogenic species such as Streptococcus mutans at micro-areas of teeth, dental restorations or implant-supported prostheses. Objective: To assess the effect of thirteen different novel lactam-based compounds on the inhibition of S. mutans biofilm formation. Material and methods: We synthesized compounds based on γ-lactones analogues from rubrolides by a mucochloric acid process and converted them into their corresponding γ-hydroxy-γ-lactams by a reaction with isobutylamine and propylamine. Compounds concentrations ranging from 0.17 up to 87.5 μg mL-1 were tested against S. mutans. We diluted the exponential cultures in TSB and incubated them (37°C) in the presence of different γ-lactones or γ-lactams dilutions. Afterwards, we measured the planktonic growth by optical density at 630 nm and therefore assessed the biofilm density by the crystal violet staining method. Results: Twelve compounds were active against biofilm formation, showing no effect on bacterial viability. Only one compound was inactive against both planktonic and biofilm growth. The highest biofilm inhibition (inhibition rate above 60%) was obtained for two compounds while three other compounds revealed an inhibition rate above 40%. Conclusions: Twelve of the thirteen compounds revealed effective inhibition of S. mutans biofilm formation, with eight of them showing a specific antibiofilm effect.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Applied Oral Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLactonespt_BR
dc.subjectLactamspt_BR
dc.subjectBiofilmpt_BR
dc.subjectAntimicrobialpt_BR
dc.subjectStreptococcus mutanspt_BR
dc.subject.otherBiofilmept_BR
dc.subject.otherProdutos de ação antimicrobianapt_BR
dc.titleEffect of γ-lactones and γ-lactams compounds on Streptococcus mutans biofilmspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/jaos/a/XfCwY4qzc6BH9DrdQvFGgYp/?lang=enpt_BR
dc.identifier.orcidhttps://doi.org/10.1590/1678-7757-2017-0065pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Effect of γ-lactones and γ-lactams compounds on Streptococcus mutans biofilms.pdf21.66 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.