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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59341
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dc.creatorFernanda L. Ferreirapt_BR
dc.creatorVanessa G. Rodriguespt_BR
dc.creatorFernando C. Silvapt_BR
dc.creatorBibiane L. G. Matildespt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.creatorGracia D. F. Silvapt_BR
dc.creatorLucienir P. Duartept_BR
dc.creatorDjalma M. Oliveirapt_BR
dc.creatorSidney A. V. Filhopt_BR
dc.date.accessioned2023-10-09T23:18:26Z-
dc.date.available2023-10-09T23:18:26Z-
dc.date.issued2017-
dc.citation.volume27pt_BR
dc.citation.spage471pt_BR
dc.citation.epage474pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bjp.2016.12.006pt_BR
dc.identifier.issn0102-695Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59341-
dc.description.resumoThe phytochemical study of the extract leaves from Maytenus distichophylla Mart. and Salacia crassifolia (Mart. ex Schult.) G. Don, Celastraceae, resulted in the isolation of 3-oxofriedelane, 3-hydroxyfriedelane, 3,24-dihydroxyfriedelane, 3-oxo-28,29-dihydroxyfriedelane, two mixtures of pentacyclic triterpenes (-amyrin with -amyrin and 3-stearyloxy-urs-12-ene with 3-stearyloxy-olean-12-ene), 3- palmityloxy-urs-12-ene, the steroid -sitosterol and its glycosylated derivative -glucosyl--sitosterol, tritriacontanoic acid and the natural polymer gutta percha. The chemical structures of these constituents were established by IR, 1H and 13C NMR spectral data. Crude extracts, the mixtures of triterpenes and the isolated constituents were subjected to in vitro acetylcholinesterase inhibitory evaluation. Acetylcholinesterase inhibitory effect was observed for crude chloroform extract leaves from M. distichophylla (100%) and S. crassifolia (97.93 ± 5.63%) and for the triterpenes 3,24-dihydroxyfriedelane (99.05 ± 1.12%), 3-oxo-28,29-dihydroxyfriedelane (90.59 ± 3.76%) and 3-palmityloxy-urs-12-ene (97.93 ± 1.47%). The percent inhibitions induced by these natural products were very similar to those produced by physostigmine (93.94 ± 2.10%) a standard acetylcholinesterase inhibitor. Therefore, these results open perspectives for the use of these species as source of compounds with similar physostigmine pharmacological effect.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINOpt_BR
dc.publisher.departmentFAE - FACULDADE DE EDUCAÇÃOpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Brasileira de Farmacognosiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCelastraceaept_BR
dc.subjectAcetylcholinesterasept_BR
dc.subjectNatural productspt_BR
dc.subjectPentacyclic triterpenespt_BR
dc.subjectPhysostigminept_BR
dc.subject.otherProdutos naturaispt_BR
dc.subject.otherFitoquímicospt_BR
dc.titleMaytenus distichophylla and Salacia crassifolia: source of products with potential acetylcholinesterase inhibitionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0102695X1630206X?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4651-3840pt_BR
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