1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59342
Full metadata record
DC FieldValueLanguage
dc.creatorGabriel Franco dos Santospt_BR
dc.creatorRondinelle Gomes Pereirapt_BR
dc.creatorMaria Amélia Diamantino Boaventurapt_BR
dc.creatorFrancisco a Maciaspt_BR
dc.creatorGesiane da Silva Limapt_BR
dc.creatorAmanda Cristina Soares Coelhopt_BR
dc.creatorJosé María González Molinillopt_BR
dc.creatorAntonio Calapt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.date.accessioned2023-10-09T23:18:49Z-
dc.date.available2023-10-09T23:18:49Z-
dc.date.issued2017-
dc.citation.volume40pt_BR
dc.citation.issue9pt_BR
dc.citation.spage1045pt_BR
dc.citation.epage1050pt_BR
dc.identifier.doihttps://doi.org/10.21577/0100-4042.20170112pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59342-
dc.description.resumoAlzheimer's disease is an irreversible, degenerative and age-related disease which is growing more and more with the increase in life expectancy. Kaurane diterpenes are a class of natural products available in large amounts in nature and isolated from plants grown worldwide. In the present work¸ twenty-seven kaurane diterpenes of natural origin and some readily available derivatives were assayed for acetylcholinesterase inhibition and the structure-activity relationship was analyzed. The kaurenoic acid derivatives screened showed to be promising inhibitors of AChE, which could provide new leads for drugs to fight Alzheimer's disease symptoms. Among them, eleven compounds showed activities comparable or higher than the positive control galantamine. Existence of an allylic hydroxyl group showed to be an important structural feature for AChE inhibition. In addition, presence of free hydroxyl groups at C-17 and C-19, furnished a diol especially active, able to completely inhibit AChE.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofQuímica Novapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectKaurane diterpenespt_BR
dc.subjectAcetylcholinesterase inhibitorspt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subject.otherDiterpenospt_BR
dc.subject.otherAlzheimer, Doença dept_BR
dc.titleStructure-activity relationship study of diterpenes for treatment of Alzheimer's diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/qn/a/GDtjZBmh8pWMyzyRBSQLd6S/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4651-3840pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF DITERPENES FOR TREATMENT OF ALZHEIMER'S DISEASE.pdf268.49 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.