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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59344
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dc.creatorMatheus Thomaz Nogueira Silvalimapt_BR
dc.creatorLarissa Batista Dos Santospt_BR
dc.creatorRafael Wesley Bastospt_BR
dc.creatorJacques Robert Nicolipt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.date.accessioned2023-10-09T23:19:42Z-
dc.date.available2023-10-09T23:19:42Z-
dc.date.issued2017-
dc.citation.volume49pt_BR
dc.citation.issue1pt_BR
dc.citation.spage169pt_BR
dc.citation.epage176pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bjm.2017.06.004pt_BR
dc.identifier.issn1517-8382pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59344-
dc.description.resumoMajor health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor (suberohydroxamic acid). Extracts from T. islandicus cultured or not with hydralazine inhibited Listeria monocytogenes growth in 57.66 ± 5.98% and 15.38 ± 1.99%, respectively. Increment in inhibition of acetylcholinesterase activity was observed for the extract from P. janthinellum grown with procainamide (100%), when compared to the control extract (39.62 ± 3.76%). Similarly, inhibition of acetylcholinesterase activity increased from 20.91 ± 3.90% (control) to 92.20 ± 3.72% when the tested extract was obtained from T. pinophilus under a combination of suberohydroxamic acid and procainamide. Concluding, increases in antimicrobial activity and acetylcholinesterase inhibition were observed when fungal extracts in the presence of DNA methyltransferases and/or histone deacetylase modulators were tested.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntimicrobial activitypt_BR
dc.subjectAcetylcholinesterase inhibitionpt_BR
dc.subjectEpigenetic modulationpt_BR
dc.subjectPenicillium sp.pt_BR
dc.subjectTalaromyces sp.pt_BR
dc.subject.otherFungospt_BR
dc.subject.otherProdutos de ação antimicrobianapt_BR
dc.titleAntimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungipt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1517838216309339?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4651-3840pt_BR
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